Research Updates

The Brain’s Lymphatic System

Modern science has an incredibly thorough understanding of the human body. It is hard to imagine that any organ or system could exist within the body that has yet to be discovered. Yet this is exactly what happened in 2015, when researchers discovered lymphatic vessels around and within the brain.

CIRCUITS: A Consortium Approach to Understanding the Epigenetics of Alzheimer's

In December, Cure Alzheimer’s kicked off one of the most ambitious projects it has funded—the Collaboration to Infer Regulatory Circuits and to Uncover Innovative Therapeutic Strategies, or CIRCUITS.

Alzheimer’s and the Gut Microbiome

It may not be surprising to learn that brain health is intricately linked to the state of the rest of the body. But what are the links, and what role do these connections play in diseases like Alzheimer’s? Sam Sisodia, Ph.D., of the University of Chicago, is examining one of the most important connections: the way in which our gut microbiome influences the brain in Alzheimer’s disease.

Cure Alzheimer’s Fund and Rotary Co-Fund Research on Women and Alzheimer’s

Cure Alzheimer’s Fund and Rotary joined forces this fall to fund research into why women are more likely to get Alzheimer’s disease than men.

Rotary and Cure Alzheimer's Fund Co-Sponsor Research Focusing on Why Women Get Alzheimer's More Than Men

(CHICAGO, IL) – OCTOBER 7, 2016 – Rotary and Cure Alzheimer’s Fund today announced an agreement to co-fund a new, groundbreaking research project to search for female-specific genetic and other factors contributing to women’s risk for Alzheimer’s disease. In total, the two organizations will provide a grant of $375,000 for this critical research.

Protecting Synapses in Adults: An Early Intervention for Alzheimer’s?

What do the developing brain and the Alzheimer’s brain have in common? Beth Stevens, Ph.D., a developmental neurologist, is investigating an important connection: the loss of synapses, where neurons connect with one another to transmit important signals.

Air Pollution and Alzheimer's: Sound the Alarm

New evidence—funded by Cure Alzheimer’s Fund (CAF) and others—has emerged suggesting a strong connection between air pollution and Alzheimer’s disease. “These findings underscore the complexity of this disease,” says CAF President and CEO Tim Armour, “and emphasize the need for a comprehensive approach to stop it.” 

New Insights Into the Blood-Brain Barrier

Three recent discoveries have clarified one of the least-understood elements of Alzheimer’s disease: how the blood-brain barrier becomes compromised and contributes to the disease process.

Driving Genes to Therapies

Building on its enormously successful “Whole Genome Sequencing” Project, which identified nearly 1,000 new genetic mutations in more than 50 different genes, Cure Alzheimer's Fund has announced a new, even more ambitious multiyear, $50 million plus program titled “Genes to Therapies” (G2T). Simply put, the new project’s goal is to use the most promising recent genetic discoveries to develop drugs that would stop the disease at three separate stages: