Research

Unique Research Funding Strategy

Cure Alzheimer’s Fund (CAF) takes a venture capital approach to medical research by finding the visionaries in the field, supporting them, focusing on the essentials by establishing a frugal culture and daring to be great. Our research objective is to support the scientists doing the most innovative work that will move knowledge of Alzheimer’s pathology most expeditiously to prevention and cure.

Our research follows a Research Roadmap designed by leading Alzheimer’s researchers who form the CAF Research Consortium. Proposals typically arise from members of the Consortium for their own work or complementary projects with or by others. Proposals are brief, with an emphasis on objectives, proposed outcomes, method and supporting data. They are reviewed by the chair of our Research Consortium and then by members of the Scientific Advisory Board. No scoring rubric is used; rather, questions or concerns are related to the researcher, who then may modify or explain the proposal accordingly. Mid-year and final reports are required. With sufficient reason to continue, some projects may be funded beyond one year. We do not accept unsolicited proposals, nor do we fund indirect costs or overhead at host institutions. Approval usually takes about two weeks, with funds delivered to the host institution within three weeks.

Latest Research Updates

Promising Update on Efficacy and Safety of “Molecular Tweezers”

Five new publications by Gal Bitan, Ph.D., and colleagues of the David Geffen School of Medicine at UCLA have been released on developing the "molecular tweezer"* CLR01 as a therapeutic drug for Alzheimer's disease and other amyloidoses (conditions involving the build-up of insoluble amyloid proteins).

Diagnosing Alzheimer’s: New Blood Test Suggests Possible Breakthrough

A new blood test, which has the potential to accurately diagnose Alzheimer’s disease in individuals and significantly advance drug testing and research on the disease, has been developed through grant funding by Cure Alzheimer's Fund. 

The test, known as Immunosignature (IS) and developed by a team led by UCLA neurologist Lucas Restrepo, uses a special method of fluorescent tagging of antibodies in the blood to recognize an identifiable binding pattern—or antibody "signature"—associated with Alzheimer's. 

Stem Cell Model of Familial Alzheimer's Identifies New AD Genes

A stem cell model of familial Alzheimer’s disease (FAD) was successfully generated in a recent study, allowing researchers to identify 14 genes potentially implicated in the disease. One gene in particular demonstrates the important role inflammation may play in the brain of Alzheimer’s patients. The study was completed by scientists at The New York Stem Cell Foundation (NYSCF) Research Institute in collaboration with scientists at the Icahn School of Medicine at Mount Sinai (ISMMS) and funded in part by the Cure Alzheimer’s Fund (CAF).

Living Brain Cells Created from Biobanked Alzheimer's Brain Tissue

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute, working in collaboration with scientists from Columbia University Medical Center (CUMC), for the first time generated induced pluripotent stem (iPS) cells lines from non-cryoprotected brain tissue of patients with Alzheimer’s disease.

Circadian Clock Proteins a Potential Therapeutic Target for Alzheimer’s

Brain aging is associated with lower production of circadian clock proteins, which synchronize biological processes to light and dark cycles. In Alzheimer’s and other neurodegenerative diseases, circadian dysfunction is commonly observed.