Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers that result from Cure Alzheimer’s Fund support.

Most of the papers grow out of the Alzheimer’s Genome Project™ (AGP), as that is where most of our investment has gone. The AGP has met its goal of identifying most of the remaining genes that affect risk or provide protection from Alzheimer’s disease in three years for about $3 million. Some 70 genes have been newly identified and now are available for follow up by Cure Alzheimer’s Fund-supported researchers and others.

The other papers represent innovative and in most cases collaborative investigations of more “translational” research–research enabled by the discovery of the first four genes that have been known to the field for some time. These papers point to ways for potentially faster development of therapies that affect the disease mechanism, not just the symptoms.

We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate all of them for the important work reflected in these papers. We also are grateful to all of those who literally made this work possible. Without those of you who have supported Cure Alzheimer’s Fund projects through your generosity, these papers and the momentum forward they represent would not exist.

2010

Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA, The COPD genetic association compendium: a comprehensive online database of COPD genetic associations, Hum. Mol. Genet., 10.1093/hmg/ddp519, Feb 1, 2010
Wei W, Nguyen L, Kessels HW, Hagiwara H, Sisodia S, Malinow R, Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience, 13(2), Feb 2010, 190-196
Silva S, Alacoque X, Fourcade O, Samii K, Marque P, Woods R, Mazziotta J, Chollet F, Loubinoux I, Wakefulness and loss of awareness: Brain and brainstem interaction in the vegetative state, Neurology, 74(4), Jan 26, 2010, 313-20
Giedraitis V, Glaser A, Sarajarvi T, Brundin R, Gunnarsson MD, Schjeide B-M, Tanzi RE, Helisalmi S, Pirttila T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M, CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid, Neuroscience Letters, Volume 469, Issue 2, Jan 22 2010, 265-267
Lill CM, Bertram L, Online databases and systematic meta-analyses of genetically complex diseases, Medizin Genet, 22, 2010, 235-241
Lublin AL, Gandy S, Amyloid-β Oligomers: Possible Role as Key Neurotoxins in Alzheimer's Disease, Mount Sinai Joural of Medicine, 77, January 2010, 43-9

2009

Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins R, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T, Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction, The Journal of Biological Chemistry, 284(52), Dec 25, 2009, 36024-33
Choi SH, Li Y, Parada LF, Sisodia SS, Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4, Dec 21, 2009, 52
Steele JW, Kim HS, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PSG, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S, Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo, Molecular Neurodegeneration, 4:51, Dec 17, 2009
Kaufer D, Gandy S., APOE ε4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics, Neurology, 73(24), Dec 15, 2009, 2052-3
Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JSK, CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease, Neurology, 73(23), December 8, 2009, 1982-7
Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM, Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle, Science, 326(5955), Nov 13, 2009, 1005-7
Zhang Y-w, Liu Shijie, Zhang X, Li W-B, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen S, Greengard P, Liao F-F, Li L, Xu H, A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation, Neuron, 64(3), Nov 12, 2009, 328-40
Won S, Bertram L, Becker D, Tanzi RE, Lange C., Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family - Based Association Tests, Statistics in Biosciences, 1(2), Nov 2009, 125-143
Nygaard HB, Strittmatter SM, Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers, Archives of Neurology, 66(11), Nov 2009, 1325-8
Liao M-C, Ahmed M, Smith SO, Norstrand WEV, Degradation of Amyloid β Protein by Purified Myelin Basic Protein, The Journal of Biological Chemistry, 284(42), October 16, 2009, 28917-28925
Bertram, L, Tanzi RE, Genome-wide association studies in Alzheimer's disease, Human Molecular Genetics, Vol 18, Review Issue 2, Oct 15, 2009
Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliot K, Wagner SL, Moir RD, Becker KD, Tanzi RE., Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity., Human Molecular Genetics, Vol 18, Oct 15, 2009
Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee J-M, Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice, The Journal of Neuroscience, 29(34), Aug 26 2009, 10706-10714
Hooli BV, Tanzi RE, A current view of Alzheimer's disease, F1000 Biology Rep., 1, July 8, 2009, 54
Cao C, Cirrito JR, Lin X, Wang L, Verges DK, Dickson A, Mamcarz M, Zhang C, Mori T, Arendash GW, Holtzman DM, Potter H, Caffeine suppresses beta-amyloid levels in plasma and brain of Alzheimer's transgenic mice., Journal of Alzheimer's disease, July 2009
Hoos MD, Ahmed M, Smith SO, Van Nostrand WE, Myelin basic protein binds to and inhibits the fibrillar assembly of Aß42 in vitro, Biochemistry, 48, June 9, 2009, 4720-4727
Bertram L, Alzheimer's Disease Genetics: Current Status and Future Perspectives, International Review of Neurobiology, Vol. 84, 2009
Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z, The Common Inhalational Anesthetic Sevoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels, Archives of Neurology, Vol. 66 No. 5, May 2009
Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., and Glabe, C, Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer, J Biol Chem, 284, February 13, 2009, 4230-4237
Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, and Bertram L., Assessment of Alzheimer's disease case-control associations using family-based methods, Neurogenetics, DOI 10.1007/s10048-008-1051-3,, Feb 10, 2009, 568-580
Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF, Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides, Angewandte Chemi International Edition, Volume 48 Issue 8, February 9, 2009, 1487–1489
Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L, GAB2 as an Alzheimer Disease Susceptibility Gene, Follow up of Genomewide Association Results, Arch Neurol, 66, Feb 2009, 250 – 254

2008

Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE., No association between CALHM1 and Alzheimer's disease risk., Cell, 135(6), Dec 12 2008, 993-4
Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. , The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo., Annals of Neurology, Volume 64, Dec 2008
Cotton RG, Auerbach AD, Axton M, Barash CI, Berkovic SF, Brookes AJ, Burn J, Cutting G, den Dunnen JT, Flicek P, Freimer N, Greenblatt MS, Howard HJ, Katz M, Macrae FA, Maglott D, Möslein G, Povey S, Ramesar RS, Richards CS, Seminara D, Smith TD, Sobrido MJ, Solbakk JH, Tanzi RE, Tavtigian SV, Taylor GR, Utsunomiya J, Watson M, The Human Variome Project, Science., 322(5903), Nov 7 2008, 861-2
Bertram L, Lange CL, Mullin K, Parkinson M, Hsiao M, Hogan MF,  Schjeide BMM, Hooli B, DeVito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE., Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE, Am. J. Hum. Genet., 83, November 2008, 623-632
Glabe, CG, Structural classification of toxic amyloid oligomers, J Biol Chem, 283, October 31, 2008, 29639-29643
Kavvoura FK, McQueen MP, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JPA., Evaluation of the potential excess of statistically significant findings reported genetic association studies: application to Alzheimer's disease, Am. J. Epidemiol., October 15, 2008
Lagace D, Benavides D, Kansy J, Mapelli M, Greengard P, Bibb J, Eisch A, Cdk5 is essential for adult hippocampal neurogenesis, Proceedings of the National Academy of Science, Vol. 105 No. 47, October 9, 2008, 18567-18571
Bertram L, Tanzi RE, Thirty years of Alzheimer’s disease genetics: the implications of systematic meta-analyses, Nature Reviews Neurosci., October 2008
Schaffer B, Bertram L, Miller L, Mullin K, Weintraub S, Johnson N, Bigio E, Mesulam M, Wiedau-Pazos M, Jackson G, Cummings J, Cantor R, Levey A, Tanzi RE, and Geschwind D, Association of GSK3B with Alzheimer's Disease and Frontotemporal Dementia, Arch. Neurol., 65(10), October 2008, 1368-1374
Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM, Amyloid-beta dynamics correlate with neurological status in the injured human brain, Science, 321(5893), Aug 29, 2008, 1221-4
Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS, Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation, Neuron, Volume 59, Issue 4, August 28, 2008, 568-580
Brody DL, Holtzman DM, Active and Passive Immunotherapy for Neurodegenerative Disorders, Annu Rev Neurosci., 31, July 2008, 175–193
Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z, The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions., J Biol Chem., 2;283(18), May 2, 2008, 11866-75
Berman DE, Dall’Armi C, Voronov SV, McIntire LBJ, Zhang H, Moore AZ, Staniszewski A, Arancio O, Kim T, Di Paolo G., Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4, 5-bisphosphate metabolism., Nature Neuroscience, May 2008
Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z., Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine., J Neurosci, 28, April 23, 2008, 4551-60
Cirrito JR, Kang J, Lee J, Stewart FR, Verges D, Silverio LM, Bu G, Mennerick S, Holtzman DM., Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo., Neuron, 58(1), April 10, 2008, 42-51

2007

Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., et al, Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers, Mol Neurodegener, 2(18), Sep 26, 2007, 1-11
Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS, Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin), J Neurosci, (26), 2007, 7006-7010
Tesco G, Koh YH, Kang E, Cameron A, Das S, Sena-Esteves M, Hiltunen, Yang S-H, Zhong Z, Shen Y, Simpkins J, Tanzi RE., Depletion of GGA3 stabilizes BACE and enhances β-secretase activity, Neuron, 54(5), 2007, 721-37
Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM, Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity, Neurology, Vol. 75/no. 7, June 2007, 595-602
Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE, Decreased catalytic activity of the insulin degrading enzyme in chromosome 10-linked Alzheimer’s disease families., Journal of Biological Chemistry, 282(11), 2007, 7825-32