Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers resulting from our research grants. The researchers we have funded have published nearly 200 papers, which have been cited over 10,300 times. The work reflected in these papers has helped us to better understand Alzheimer’s and find ways to intervene that may lead to slowing or reversing the disease. We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate them for the important work they are doing. We also are grateful to our donors, who have made this work possible. Without your support and generosity, these papers and the forward momentum they represent would not exist.

2012

Lill CM, Schjeide BM, Akkad DA, Blaschke P, Winkelmann A, Gerdes LA, Hoffjan S, Luessi F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Bertram L, Zipp F, Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample, Neurogenetics, 13(1), February 2012, 83-6
Sungho Wona, Qing Luc, Lars Bertram, Rudolph E. Tanzi, Christoph Lange, On the Meta-Analysis of Genome-Wide Association Studies: A Robust and Efficient Approach to Combine Population and Family-Based Studies, Human Heredity , 73, January 18, 2012, 35-46
Yuanlin Dong, Xu Wu, Zhipeng Xu, Yiying Zhang, Zhongcong Xie, Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation, PLoS One, 7(6), 2012
Lebedeva E, Stingl JC, Thal DR, Ghebremedhin E, Strauss J, Özer E, Bertram L, von Einem B, Tumani H, Otto M, Riepe MW, Högel J, Ludolph AC, von Arnim CA, Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD, Neurobiol Aging, 33(1), January 2012, 201.e9-201.e18

2011

Bertram L, Hampel H, The role of genetics for biomarker development in neurodegeneration, Prog Neurobiol., 95(4), December 2011, 501-4
Lill CM, Bertram L, Towards unveiling the genetics of neurodegenerative diseases, Semin Neurol., 31(5), November 2011, 531-41
Prinz M, Priller J, Sisodia SS, Ransohoff RM, Heterogeneity of CNS myeloid cells and their roles in neurodegeneration, Nat Neurosci., 14(10), 2011 Sept 27, 1227-35
Haworth A, Bertram L, Carrera P, Elson JL, Braastad CD, Cox DW, Cruts M, den Dunnen JT, Farrer MJ, Fink JK, Hamed SA, Houlden H, Johnson DR, Nuytemans K, Palau F, Rayan DL, Robinson PN, Salas A, Schüle B, Sweeney MG, Woods MO, Amigo J, Cotton RG, Sobrido MJ, Call for participation in the neurogenetics consortium within the Human Variome Project, Neurogenetics, 12(3), August 2011, 169-73
Bertram, L, Alzheimer’s genetics in the GWAS era: a continuing story of ‘replications and refutations’, Curr Neurol Neurosci Rep., 11(3), June 2011, 246-53
Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M, Cysteine 27 Variant of the δ-Opioid Receptor Affects Amyloid Precursor Protein Processing through Altered Endocytic Trafficking, Mol Cell Biol., 31(11), June 2011, 2326–2340
A. Li, C. Zhou, J. Moore, P. Zhang, T.-H. Tsai, H.-C. Lee, D.M. Romano, M.L. McKee, D.A. Schoenfeld, M.J. Serra,3 K. Raygor, H.F. Cantiello, J.G. Fujimoto, and R.E. Tanzi, Changes in the Expression of the Alzheimer’s Disease- Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction, NIHPA Author Manuscripts , 8/3, May 1, 2011, 313-322
Thomas Pfeiffer, Lars Bertram, John P. A. Ioannidis, Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias, Plos One, 6:3 , March 29, 2011
Viswanathan J, Haapasalo A, Bottcher C, Miettinen R, Kurkinen KMA, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Nertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M, Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation, Traffic, 12(3), Mar 12, 2011, 330-48
Jing L. Guo and Virginia M.-Y. Lee, Seeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles, The Journal of Biological Chemistry, 286/17, March 3, 2011, 15317-15331
Brit-Maren M. Schjeide, BS; Cathrin Schnack, PhD; Jean-Charles Lambert, PhD; Christina M. Lill, MD; Julia Kirchheiner, MD, PhD; Hayrettin Tumani, MD; Markus Otto, MD; Rudolph E. Tanzi, PhD; Hans Lehrach, PhD; Philippe Amouyel, PhD; Christine A. F. von Arnim, MD; Lars Bertram, MD, The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels, Arch Gen Psychiatry, 68(2), February 7, 2011, 207-213
Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ, Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice, Journal of Cerebral Blood Flow & Metabolism, 31, January 2011, 351–61

2010

Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL, Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study, Neurobiology of Disease, Volume 40, Issue 3, Dec 2010, 555-564
Bertram L, Lill CM, Tanzi RE, The Genetics of Alzheimer Disease: Back to the Future, Neuron, 68(2), Oct 21, 2010, 270-81
Kwangwook Ahn, Christopher C. Shelton, Yuan Tian, Xulun Zhang, M. Lane Gilchrist, Sangram S. Sisodia, and Yue-Ming Li, Activation and Intrinsic γ-Secretase Activity of Presenilin 1, Proc. Natl. Acad. Sci USA, 50, Oct 15, 2010, 21435–21440
Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S, Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex, The Journal of Neuroscience, 30(39), Sep 29, 2010, 13110-13115
Zhang C, Browne A, Child D, Tanzi RE, Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein, The Journal of Biological Chemistry, 285(37), Sep 10, 2010, 28472-80
Hu WT, McMillan C, Libon D, Leight S, Forman M, Lee VM-Y, Trojanowski JQ, Grossman M, Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia, Neurology, 75(7), Aug 17, 2010, 595-602
Kessels HW, Nguyen LN, Nabavi S, Malinow R, The prion protein as a receptor for beta-amyloid, Nature, 466(7308), Aug 12, 2010, E3-E5
Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME, Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers, Annals of Neurology, Volume 68, Issue 2, August 2010
Huttunen HJ, Hutter-Paier B, Barren C, Peach C, Havas D, Duller S, Xia W, Frosch MP, Windisch M, Kovacs DM., The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice, Journal of Neuropathology and Experimental Neurology, 69(8), August 2010, 777-88
Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE, Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome, PLoS ONE, 5(5), May 20, 2010
Dolan SM, Hollegaard MV, Merialdi M, Betran AP, Allen T, Abelow C, Nace J, Lin BK, Khoury MJ, Ioannidis JP, Bagade S, Zheng X, Dubin RA, Bertram L, Velez Edwards DR, Menon R, Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene), Public Health Genomics, 13(7-8), May 20, 2010, 514-23
Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Lauren J, Gimbel ZA, Strittmatter SM, Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein, The Journal of Neuroscience, 30(18), May 5, 2010, 6367-6374
Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ, Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP, The Journal of Neuroscience, 30(17), Apr 28 2010, 5948-5957
Zhang C, Browne A, Child D, DiVito JR, Stevenson JA, Tanzi RE, Loss-of-Function of ATXN1 Increases Amyloid-Beta Levels by Potentiating Beta-Secretase Processing of APP, Journal of Biological Chemistry, 285(12), Mar 19, 2010, 8515-26
Kim SH, Fraser PE, Westaway D, George-Hyslop PH, Ehrlich ME, Gandy S, Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid β42 from Isolated Intact Nerve Terminals, The Journal of Neuroscience, 30(11), Mar 17, 2010, 3870-3875
Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, delMonte F., Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy, Circulation: Journal of the American Heart Association, 121(10), Mar 16, 2010, 1216-26
Zeng C, Pan F, Jones LA, Lim MM, Griffin EA, Sheline YI, Mintun MA, Holtzman DM, Mach RH, Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system, Brain Research, Volume 1319, Mar 10 2010, 21-32
Wei W, Nguyen L, Kessels HW, Hagiwara H, Sisodia S, Malinow R, Amyloid beta from axons and dendrites reduces local spine number and plasticity, Nature Neuroscience, 13(2), Feb 2010, 190-196
Sleegers K, Lambert J-C, Bertram L, Cruts M, Amouyel P, Broeckhoven CV, The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects, Trends in Genetics, Volume 26, Issue 2, February 2010, 84-93
Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA, The COPD genetic association compendium: a comprehensive online database of COPD genetic associations, Hum. Mol. Genet., 10.1093/hmg/ddp519, Feb 1, 2010
Silva S, Alacoque X, Fourcade O, Samii K, Marque P, Woods R, Mazziotta J, Chollet F, Loubinoux I, Wakefulness and loss of awareness: Brain and brainstem interaction in the vegetative state, Neurology, 74(4), Jan 26, 2010, 313-20
Giedraitis V, Glaser A, Sarajarvi T, Brundin R, Gunnarsson MD, Schjeide B-M, Tanzi RE, Helisalmi S, Pirttila T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M, CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid, Neuroscience Letters, Volume 469, Issue 2, Jan 22 2010, 265-267
Lublin AL, Gandy S, Amyloid-β Oligomers: Possible Role as Key Neurotoxins in Alzheimer's Disease, Mount Sinai Joural of Medicine, 77, January 2010, 43-9
Lill CM, Bertram L, Online databases and systematic meta-analyses of genetically complex diseases, Medizin Genet, 22, 2010, 235-241

2009

Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins R, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T, Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction, The Journal of Biological Chemistry, 284(52), Dec 25, 2009, 36024-33
Choi SH, Li Y, Parada LF, Sisodia SS, Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4, Dec 21, 2009, 52
Steele JW, Kim HS, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PSG, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S, Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo, Molecular Neurodegeneration, 4:51, Dec 17, 2009
Kaufer D, Gandy S., APOE ε4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics, Neurology, 73(24), Dec 15, 2009, 2052-3
Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JSK, CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease, Neurology, 73(23), December 8, 2009, 1982-7
Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM, Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle, Science, 326(5955), Nov 13, 2009, 1005-7
Zhang Y-w, Liu Shijie, Zhang X, Li W-B, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen S, Greengard P, Liao F-F, Li L, Xu H, A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation, Neuron, 64(3), Nov 12, 2009, 328-40
Nygaard HB, Strittmatter SM, Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers, Archives of Neurology, 66(11), Nov 2009, 1325-8