Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers resulting from our research grants. The researchers we have funded have published nearly 200 papers, which have been cited over 10,300 times. The work reflected in these papers has helped us to better understand Alzheimer’s and find ways to intervene that may lead to slowing or reversing the disease. We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate them for the important work they are doing. We also are grateful to our donors, who have made this work possible. Without your support and generosity, these papers and the forward momentum they represent would not exist.

2015

Yuk Yee Leung, Jon B. Toledo, Alexey Nefedov, Robi Polikar, Nandini Raghavan, Sharon X. Xie, Michael Farnum, Tim Schultz, Young Baek, Vivianna M. Van Deerlin, William T. Hu, David M. Holtzman, Anne M. Fagan, Richard J. Perrin, Murray Grossman, Holly D. Soares, Mitchel A. Kling, Matthew Mailman, Steven E. Arnold, Vaibhav A. Narayan, Virginia M-Y. Lee, Leslie M. Shaw, David Baker, Gayle M. Wittenberg, John Q. Trojanowski, and Li-San Wang, Identifying amyloid pathology–related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 1(3), September 2015, 339-348
Adam Cantlon, Carlo Sala Frigerio, and Dominic M. Walsh, Lessons from a Rare Familial Dementia: Amyloid and Beyond, Journal of Parkinson's Disease and Alzheimer's Disease, 2(1), August 2015
Pavel V. Belichenko, Alexander M. Kleschevnikov, Ann Becker, Grant E. Wagner, Larisa V. Lysenko, Y. Eugene Yu, and William C. Mobley, Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues, PLoS One, 10(7), July 2015
Octavian Adam, M.D., Christine L. Mac Donald, Ph.D., Dennis Rivet, M.D., John Ritter, M.D., Todd May, D.O., Maria Barefield, O.T.D., Josh Duckworth, M.D., Donald LaBarge, M.D., Dean Asher, M.D., Benjamin Drinkwine, M.D., Yvette Woods, Ph.D., Michael Connor, Psy.D. and David L. Brody, M.D., Ph.D., Clinical and imaging assessment of acute combat mild traumatic brain injury in Afghanistan, Neurology, 85(3), 21 July 2015, 219-227
Dmitry Prokopenko , Julian Hecker, Edwin Silverman, Markus M. Nöthen, Matthias Schmid, Christoph Lange, Heide Loehlein Fier, Using Network Methodology to Infer Population Substructure, Plos, June 22, 2015
Virginie Buggia-Prévot, Gopal Thinakaran, Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons, BioEssays, 37(7), June 2015
Christina M. Lill MD, Johnni Hansen PhD, Jørgen H. Olsen MD, Harald Binder PhD, Beate Ritz MD, PhD and Lars Bertram MD, Impact of Parkinson's disease risk loci on age at onset, Movement Disorders, 30(6), May 2015, 847–850
Brendan P Lucey, David M Holtzman, How amyloid, sleep and memory connect, Nature Neuroscience , 18, June 25, 2015, 933–934
Adam Cantlon, Carlo Sala Frigerio, Darragh B. Freir, Barry Boland, Ming Jin and Dominic M. Walsh, The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers, Journal of Biological Chemistry, 290, July 2015, 16502-16516
Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Jesse Cedarbaum, Michael C. Donohue, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, John C. Morris, Ronald C. Petersen, Andrew J. Saykin, Leslie Shaw, Paul M. Thompson, Arthur W. Toga, and John Q. Trojanowski, Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014, Alzheimer's & Dementia, 11(7), July 2015, 865-884
Young Hye Kim, Se Hoon Choi, Carla D'Avanzo, Matthias Hebisch, Christopher Sliwinski, Enjana Bylykbashi, Kevin J Washicosky, Justin B Klee, Oliver Brüstle, Rudolph E Tanzi & Doo Yeon Kim, A 3D human neural cell culture system for modeling Alzheimer’s disease, Nature Protocols, 10(7), June 2015, 985–1006
, Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T, Journal of Biological Chemistry, 290(22), May 2015, 14208-14217
Erik S Musiek & David M Holtzman, Three dimensions of the amyloid hypothesis: time, space and 'wingmen', Nature Neuroscience, May 2015, 800-806
Carla D’Avanzo, Christopher Sliwinski, Steven L. Wagner, Rudolph E. Tanzi, Doo Yeon Kim, and Dora M. Kovacs, γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation, The FASEB Journal, 29(8), 22 April 2015, 3335-3341
Chia-Chen Liu, Jin Hu, Chih-Wei Tsai, Mei Yue, Heather L. Melrose, Takahisa Kanekiyo, and Guojun Bu, Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain, The Journal of Neuroscience, 35(14), April 2015, 5851-5859
Kiran Yanamandra, Hong Jiang, Thomas E. Mahan, Susan E. Maloney, David F. Wozniak, Marc I. Diamond and David M. Holtzman, Anti-tau antibody reduces insoluble tau and decreases brain atrophy, Annals of Clinical and Translational Neurology, 2(3), March 2015, 278–288
Alexandra J. Mably, Daniel Kanmert, Jessica M. Mc Donald, Wen Liu, Barbara J. Caldarone, Cynthia A. Lemere, Brian O'Nuallain, Kenneth S. Kosik, Dominic M. Walsh, Tau immunization: a cautionary tale?, Neurobiology of Aging, 36(3), March 2015, 1316–1332
Michael W. Nestor, Samson Jacob, Bruce Sun, Deborah Prè, Andrew A. Sproul, Seong Im Hong, Chris Woodard, Matthew Zimmer, Vorapin Chinchalongporn, Ottavio Arancio, Scott A. Noggle, Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies, American Journal of Physiology - Cell Physiology, 308(3), Feb 2015, C209-C219
Connie Marras MD, PhD, Anthony Lang MD, Bart P. van de Warrenburg, Carolyn Sue, Sarah J. Tabrizi MBChB, PhD, Lars Bertram MD, Katja Lohmann PhD, Saadet Mercimek-Mahmutoglu MD, PhD, Alexandra Durr, Vladimir Kostic, Christine Klein MD, Recommendations of the International Parkinson and Movement Disorder Society Task Force on Nomenclature of Genetic Movement Disorders,

2014

Larisa V. Lysenko, Jeesun Kim, Cassandra Henry, Anna Tyrtyshnaia, Rebecca A. Kohnz, Francisco Madamba, Gabriel M. Simon, Natalia E. Kleschevnikova, Daniel K. Nomura, R . Alan B. Ezekowitz, and Alexander M. Kleschevnikov, Monoacylglycerol Lipase Inhibitor JZL184 Improves Behavior and Neural Properties in Ts65Dn Mice, a Model of Down Syndrome, PLoS One, 9(12), December 2014
Miranda M Lim, Jason R Gerstner. David M Holtzman, The sleep–wake cycle and Alzheimer's disease: what do we know?, Neurodegenerative Disease Management, Vol. 4, No. 5, 351-362
Riqiang Yan, Robert Vassar, Targeting the β secretase BACE1 for Alzheimer's disease therapy, The Lancet Neurology, 13(3), March 2014, 319 - 329
H. Wang, Y. Dong, J. Zhang, Z. Xu, G. Wang, C. A. Swain, Y. Zhang and Z. Xie, Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors, Br. J. Anaesth.
Zhongcong Xie, Celeste A. Swain, Sarah A. P. Ward, Hui Zheng, Yuanlin Dong, Neelakantan Sunder, Dennis W. Burke, Diana Escobar, Yiying Zhang and Edward R. Marcantonio, Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium, Annals of Clinical and Translational Neurology, 9 April 2014
Andrew A. Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W. Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W. Steele, David J. Kahler, Alex Dranovsky, Ottavio Arancio, John F. Crary, Sam Gandy, and Scott A. Noggle, Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors, PLoS ONE, 9(1), Jan 8 2014
(S38.002) Lucas Restrepo, Phillip Stafford and Stephen Johnston, High Accuracy of a Microarray-Based Blood Test for Alzheimer’s Disease (S38.002), Neurology, 82(10), April 8, 2014
Christina M. Lill, Marcel Schilling, Sara Ansaloni, Julia Schröder, Marian Jaedicke, Felix Luessi, Brit-Maren M. Schjeide, Andriy Mashychev, Christiane Graetz, Denis A. Akkad, Lisa-Ann Gerdes, Antje Kroner, Paul Blaschke, Sabine Hoffjan, Alexander Winkelmann, Thomas Dörner, Peter Rieckmann, Elisabeth Steinhagen-Thiessen, Ulman Lindenberger, Andrew Chan, Hans-Peter Hartung, Orhan Aktas, Peter Lohse, Mathias Buttmann, Tania Kümpfel, Christian Kubisch, Uwe K. Zettl, Joerg T. Epplen, Frauke Zipp, Lars Bertram, Assessment of microRNA-related SNP effects in the 3′ untranslated region of theIL22RA2 risk locus in multiple sclerosis, Neurogenetics, 15(2), March 18 2014, 129-134
David Cantu, Kendall Walker, Lauren Andresen, Amaro Taylor-Weiner, David Hampton, Giuseppina Tesco and Chris G. Dulla, Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control, Cereb. Cortex, March 7, 2014
Karthikeyan Veeraraghavalu, Can Zhang, Xiaoqiong Zhang, Rudolph E. Tanzi, and Sangram S. Sisodia, Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons, J Neurosci, 34(10), 5 March 2014, 3668-3673
Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z, Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Sci Rep, 4, January 20, 2014, 3766
Ofra Ben Menachem-Zidon, Yair Ben Menahem, Tamir Ben-Hur, Raz Yirmiya, Intra-Hippocampal Transplantation of Neural Precursor Cells with Transgenic Over-Expression of IL-1 Receptor Antagonist Rescues Memory and Neurogenesis Impairments in an Alzheimer’s Disease Model, Neuropsychopharmacology, 39(2), Jan 2014, 401-414

2013

Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi, ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function, Neuron, 80(2), Oct 16, 2013, 385–401
Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G, A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease, PLOS ONE, 8(11), November 13, 2013
Klunk WE, Perani D, Amyloid and neurodegeneration: converging and diverging paths, Neurology, 81(20), November 12, 2013, 1728-1729
Zhang X, Xin X, Dong Y, Zhang Y, Yu B, Mao J, Xie Z, Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice, J Neurosci, 33(45), November 6, 2013, 17737-17748
Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, Klunk WE, Aizenstein HJ, Cohen AD, Snitz BE, Mathis CA, Dekosky ST, Lopez OL, Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults, Neurology, 81(19), November 5, 2013, 1711-1718
Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC, Clinical presentation of chronic traumatic encephalopathy, Neurology, 81(13), September 24, 2013, 1122-1129
Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE, Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Hum Mol Genet, 22(18), September 15, 2013, 3798-3806
Rudolph E Tanzi, Decoding Alzheimer's in the age of genome-wide analyses, Mol Neurodegener, 8(suppl 1), September 13. 2013, 01
Vos SJ, Xiong C, Visser PJ, Jasielec MS, Hassenstab J, Grant EA, Cairns NJ, Morris JC, Holtzman DM, Fagan AM, Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study, The Lancet Neurology, 12(10), September 4, 2013, 957-965
Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG, Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice, J Neurochem, 126(4), August 2013, 473-482
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S, Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain, Mol Psychiatry, 18(8), August 2013, 882-888
J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim, L M Delgado, I E Alfaro, S Bernales, G Verdile, P Bharadwaj, V Gupta, R Barr, A Friss, G Dolios, R Wang, D Ringe, P Fraser, D Westaway, P H St George-Hyslop, P Szabo, N R Relkin, J D Buxbaum, C G Glabe, A A Protter, R N Martins, M E Ehrlich, G A Petsko, Z Yue and S Gandy, Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model, Mol Psychiatry, 18(8), Aug 2013, 889-897
Walker KR, Tesco G, Molecular mechanisms of cognitive dysfunction following traumatic brain injury, Front Aging Neurosci, 5(29), July 9, 2013
Raja Bhattacharyya, Cory Barren, Dora M. Kovacs, Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts, The Journal of Neuroscience, 33(27), 3 July 2013, 11169-83
Zhongcong Xie, MD, PhD, Sayre McAuliffe, Celeste A. Swain, Sarah A. P. Ward, Catherine A. Crosby, Hui Zheng, Janet Sherman, Yuanlin Dong, Yiying Zhang, Neelakantan Sunder, Dennis Burke, Kevin Washicosky, Rudolph E. Tanzi, and Edward R. Marcantonio, Cerebrospinal Fluid Aβ to Tau Ratio and Postoperative Cognitive Change, Annals of Surgery, Ann Surg 2013;00 , 5/10/2013, 1-6
BV Hooli1, ZM Kovacs-Vajna2, K Mullin1, MA Blumenthal1, M Mattheisen3, C Zhang1, C Lange4, G Mohapatra5, L Bertram6 and RE Tanzi1, Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychology, 6/11/2013
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY, BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels, FASEB J, 27(6), June 2013, 2458-67
International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F, MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis, Brain, 1386 (Pt 6), June 2013, 1778-1782
Irene Pichler, Fabiola Del Greco M., Martin Gögele, Christina M. Lill, Lars Bertram, Chuong B. Do, Nicholas Eriksson, Tatiana Foroud, Richard H. Myers, PD GWAS Consortium, Michael Nalls, Margaux F. Keller, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium, Beben Benyamin, John B. Whitfield, Genetics of Iron Status Consortium, Peter P. Pramstaller, Andrew A. Hicks, John R. Thompson, and Cosetta Minelli, Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study, PLOS Med , 10(6), June 2013