Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers resulting from our research grants. The researchers we have funded have published nearly 200 papers, which have been cited over 10,300 times. The work reflected in these papers has helped us to better understand Alzheimer’s and find ways to intervene that may lead to slowing or reversing the disease. We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate them for the important work they are doing. We also are grateful to our donors, who have made this work possible. Without your support and generosity, these papers and the forward momentum they represent would not exist.

2013

Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, Klunk WE, Aizenstein HJ, Cohen AD, Snitz BE, Mathis CA, Dekosky ST, Lopez OL, Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults, Neurology, 81(19), November 5, 2013, 1711-1718
Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC, Clinical presentation of chronic traumatic encephalopathy, Neurology, 81(13), September 24, 2013, 1122-1129
Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE, Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Hum Mol Genet, 22(18), September 15, 2013, 3798-3806
Rudolph E Tanzi, Decoding Alzheimer's in the age of genome-wide analyses, Mol Neurodegener, 8(suppl 1), September 13. 2013, 01
Vos SJ, Xiong C, Visser PJ, Jasielec MS, Hassenstab J, Grant EA, Cairns NJ, Morris JC, Holtzman DM, Fagan AM, Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study, The Lancet Neurology, 12(10), September 4, 2013, 957-965
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S, Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain, Mol Psychiatry, 18(8), August 2013, 882-888
J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim, L M Delgado, I E Alfaro, S Bernales, G Verdile, P Bharadwaj, V Gupta, R Barr, A Friss, G Dolios, R Wang, D Ringe, P Fraser, D Westaway, P H St George-Hyslop, P Szabo, N R Relkin, J D Buxbaum, C G Glabe, A A Protter, R N Martins, M E Ehrlich, G A Petsko, Z Yue and S Gandy, Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model, Mol Psychiatry, 18(8), Aug 2013, 889-897
Walker KR, Tesco G, Molecular mechanisms of cognitive dysfunction following traumatic brain injury, Front Aging Neurosci, 5(29), July 9, 2013
Raja Bhattacharyya, Cory Barren, Dora M. Kovacs, Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts, The Journal of Neuroscience, 33(27), 3 July 2013, 11169-83
BV Hooli1, ZM Kovacs-Vajna2, K Mullin1, MA Blumenthal1, M Mattheisen3, C Zhang1, C Lange4, G Mohapatra5, L Bertram6 and RE Tanzi1, Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychology, 6/11/2013
Zhongcong Xie, MD, PhD, Sayre McAuliffe, Celeste A. Swain, Sarah A. P. Ward, Catherine A. Crosby, Hui Zheng, Janet Sherman, Yuanlin Dong, Yiying Zhang, Neelakantan Sunder, Dennis Burke, Kevin Washicosky, Rudolph E. Tanzi, and Edward R. Marcantonio, Cerebrospinal Fluid Aβ to Tau Ratio and Postoperative Cognitive Change, Annals of Surgery, Ann Surg 2013;00 , 5/10/2013, 1-6
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY, BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels, FASEB J, 27(6), June 2013, 2458-67
International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F, MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis, Brain, 1386 (Pt 6), June 2013, 1778-1782
Irene Pichler, Fabiola Del Greco M., Martin Gögele, Christina M. Lill, Lars Bertram, Chuong B. Do, Nicholas Eriksson, Tatiana Foroud, Richard H. Myers, PD GWAS Consortium, Michael Nalls, Margaux F. Keller, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium, Beben Benyamin, John B. Whitfield, Genetics of Iron Status Consortium, Peter P. Pramstaller, Andrew A. Hicks, John R. Thompson, and Cosetta Minelli, Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study, PLOS Med , 10(6), June 2013
Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr, Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, Br. J. Anaesth. , 111(2), May 30, 2013, 143-151
Zhang L, Zhang J, Yang L, Dong Y, Zhang Y, Xie Z, Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia, April 19, 2013
Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S, Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-β Peptide, J Neurosci, 33(16), April 17, 2013, 7099-7107
Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy, Traumatic Brain Injury (TBI) can lead to Neurodegenerative Syndromes that include Alzheimer Disease (AD) and Chronic Traumatic Encephalopathy (CTE), Nature Reviews Neurology, Volume 9, No 4 , April 2013, 192-200
Snitz BE, Weissfeld LA, Lopez OL, Kuller LH, Saxton J, Singhabahu DM, Klunk WE, Mathis CA, Price JC, Ives DG, Cohen AD, McDade E, Dekosky ST, Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia, Neurology, 80(15), April 9, 2013, 1378-1384
Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui HC, Jagust WJ, The aging brain and cognition: contribution of vascular injury and aβ to mild cognitive dysfunction, JAMA Neurol, 70(4), April 2013, 488-495
Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy, Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers, Nature Reviews Neurology, April 2013, 192-200
Michiyo Iba, Jing L. Guo, Jennifer D. McBride, Bin Zhang, John Q. Trojanowski, Virginia M.-Y. Lee, Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy, J NeuroScience, 33(3), January 16, 2013, 1024-1037
Lill CM, Schjeide BM, Graetz C, Liu T, Damotte V, Akkad DA, Blaschke P, Gerdes LA, Kroner A, Luessi F, Cournu-Rebeix I, Hoffjan S, Winkelmann A, Touze E, Pico F, Corcia P, Otaegui D, Antigüedad A, Alcina A, Comabella M, Montalban X, Olascoaga J, Matesanz F, Dörner T, Li SC, Steinhagen-Thiessen E, Lindenberger U, Chan A, Rieckmann P, Hartung HP, Aktas O, Lohse P, Buttmann M, Kümpfel T, Kubisch C, Zettl UK, Epplen JT, Fontaine B, Zipp F, Vandenbroeck K, Bertram L, Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk, J Med Genet, 50(30), January 12, 2013, 140-143
Shen X, Dong Y, Xu Z, Wang H, Miao C, Soriano SG, Sun D, Baxter MG, Zhang Y, Xie Z, Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment, Anesthesiology, Jan 9, 2013
Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL, Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls, Ann. Neurol, 73(1), January 1, 2013, 104-119

2012

Soong Ho Kim1, Elysse M Knight, Eric L Saunders, Azita K Cuevas, Marusia Popovech, Lung-Chi Chen, Sam Gandy, Rapid doubling of Alzheimer’s amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution, F1000Research, 1:70, Dec 21, 2012
Arai H, Glabe C, Luecke H, Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers, Biochim Biophys Acta, 1820(12), Dec 2012, 1908-14
Aida Attar, Cristian Ripoli, Elisa Riccardi, Panchanan Maiti, Domenica D. Li Puma, Tingyu Liu, Jane Hayes, Mychica R. Jones, Kristin Lichti-Kaiser, Fusheng Yang, Greg D. Gale, Chi-hong Tseng, Miao Tan, Cui-Wei Xie, Jeffrey L. Straudinger, Frank-Gerrit Klarner, Thomas Schrader, Sally A. Frautschy, Claudio Grassi and Gal Bitan, Protection of primary neurons and mouse brain from Alzheimer’s pathology by molecular tweezers, Brain, A Journal of Neurology, doi:10.1093/brain/aws289, November 26, 2012, 3735-48
Kim J, Eltorai AE, Jiang H, Liao F, Verghese PB, Kim J, Stewart FR, Basak JM, Holtzman DM, Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis, J Exp Med., 209(12), Nov 19, 2012, 2149-56
Rachel F. Lane, Peter St George-Hyslop, Barbara L. Hempstead, Scott A. Small, Stephen M. Strittmatter, and Sam Gandy, Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes, The Journal of Neuroscience, 32(41), October 10, 2012, 14080 –14086
Jee Hoon Roh,1,2,3 Yafei Huang,1 Adam W. Bero,1,2,3 Tom Kasten,1 Floy R. Stewart,1,2,3 Randall J. Bateman,1,2,3 David M. Holtzman1,2,3,4*, Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of Amyloid-b in Mice with Alzheimer’s Disease Pathology, Science Translational Medicine Home , Vol. 4, Issue 150, September 5, 2012
Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z, Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons, Curr Mol Med., Sep 3, 2012
Lill CM, Bertram L, Developing the ‘next generation’ of genetic association databases for complex diseases, Hum. Mutat., 33(9), September 2012, 1366–72
Lill CM, Liu T, Schjeide BM, Roehr JT, Akkad DA, Damotte V, Alcina A, Ortiz MA, Arroyo R, Lopez de Lapuente A, Blaschke P, Winkelmann A, Gerdes LA, Luessi F, Fernadez O, Izquierdo G, Antigüedad A, Hoffjan S, Cournu-Rebeix I, Gromöller S, Faber H, Liebsch M, Meissner E, Chanvillard C, Touze E, Pico F, Corcia P; ANZgene Consortium, Dörner T, Steinhagen-Thiessen E, Baeckman L, Heekeren HR, Li SC, Lindenberger U, Chan A, Hartung HP, Aktas O, Lohse P, Kümpfel T, Kubisch C, Epplen JT, Zettl UK, Fontaine B, Vandenbroeck K, Matesanz F, Urcelay E, Bertram L, Zipp F, Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects, J Med Genet., 49(9), September 2012, 558-62
Xie Z, Xu Z, General anesthetics and β-amyloid protein, Prog Neuropsychopharmacol Biol Psychiatry, Aug 14, 2012, 140-146
Kendall R. Walker, Eugene L. Kang, Michael J. Whalen, Yong Shen, and Giuseppina Tesco, Depletion of GGA1 and GGA3 Mediates Postinjury Elevation of BACE1, The Journal of Neuroscience, 32 (30), July 25, 2012, 10423–10437
Wagner SL, Tanzi RE, Mobley WC, Galasko D, Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease, Arch Neurol., July 16, 2012
Miyazaki T, Takase K, Nakajima W, Tada H, Ohya D, Sano A, Goto T, Hirase H, Malinow R, Takahashi T, Disrupted cortical function underlies behavior dysfunction due to social isolation, J Clin Invest., 122(7), Jul 2, 2012, 2690-701
Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z, The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β, Neurobiology of Aging, 33(7), July 2012, 1364-78
Wallace BC, Small K, Brodley CE, Lau J, Schmid CH, Bertram L, Lill CM, Cohen JT, Trikalinos TA, Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining, Genet Med., 14(7), July 2012, 663-9
Xulun Zhang1, Krassimira Garbett2, Karthikeyan Veeraraghavalu, Brian Wilburn, Reid Gilmore, Karoly Mirnics, and Sangram S. Sisodia, A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2, The Journal of Neuroscience, 32(25), June 20, 2012, 8633-8648
Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li YM, Koide S, Sisodia SS, Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies, Proc Natl Acad Sci U S A, 109(22), May 29, 2012, 8534-9
Nussbaum, JM; Schilling, S; Cynis, H; Silva, A; Swanson, E; Wangsanut, T; Tayler, K; Wiltgen, B; Hatami, A; Ronicke, R; Reymann, K; Hutter-Paier, B; Alexandru, A; Jagla, W; Graubner, S; Glabe, CG; Demuth, HU; Bloom, GS, Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β, Nature, 485, May 2, 2012, 651-655
B.V. Hooli, PhD, G. Mohapatra, PhD, M. Mattheisen, MD, A.R. Parrado, PhD, J.T. Roehr, MS, Y. Shen, PhD, J.F. Gusella, PhD, R. Moir, PhD, A.J. Saunders, PhD, C. Lange, PhD, R.E. Tanzi, PhD and L. Bertram, MD, Role of common and rare APP DNA sequence variants in Alzheimer disease, Neurology 78 , 78/16, April 17, 2012, 1250-1257
Wu-Zhang AX, Schramm CL, Nabavi S, Malinow R, Newton AC, Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory, J Biol Chem., 287(16), Apr 13, 2012, 12879-85
Bero AW, Bauer AQ, Stewart FR, White BR, Cirrito JR, Raichle ME, Culver JP, Holtzman DM, Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain, J Neurosci., 32(13), Mar 28, 2012, 4334-40
Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE, RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing, Transl Neurodegener., 1:8, Mar 22, 2012
Lill CM, Roehr JT, McQueen MB, Kavvoura FK, Bagade S, Schjeide BM, Schjeide LM, Meissner E, Zauft U, Allen NC, Liu T, Schilling M, Anderson KJ, Beecham G, Berg D, Biernacka JM, Brice A, DeStefano AL, Do CB, Eriksson N, Factor SA, Farrer MJ, Foroud T, Gasser T, Hamza T, Hardy JA, Heutink P, Hill-Burns EM, Klein C, Latourelle JC, Maraganore DM, Martin ER, Martinez M, Myers RH, Nalls MA, Pankratz N, Payami H, Satake W, Scott WK, Sharma M, Singleton AB, Stefansson K, Toda T, Tung JY, Vance J, Wood NW, Zabetian CP; 23andMe Genetic Epidemiology of Parkinson's Disease Consortium; International Parkinson's Disease Genomics Consortium; Parkinson's Disease GWAS Consortium; Wellcome Trust Case Control Consortium 2), Young P, Tanzi RE, Khoury MJ, Zipp F, Lehrach H, Ioannidis JP, Bertram L, Comprehensive research synopsis and systematic meta-analyses in Parkinson’s disease genetics: The PDGene database, PLoS Genet., 8(3), March 2012, e1002548
Yiying Zhang MD, MS1, Zhipeng Xu MD, PhD1, Hui Wang MD1,2, Yuanlin Dong MD, MS1, Hai Ning Shi PhD, DVM3, Deborah J. Culley MD4, Gregory Crosby MD4, Edward R. Marcantonio MD5, Rudolph E. Tanzi PhD.6, Zhongcong Xie MD, PhD1,*, Anesthetics Isoflurane and Desflurane Differently Affect Mitochondrial Function, Learning, and Memory, Annals of Neurology, Volume 71, Issue 5, February 24, 2012, 687–698