Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers resulting from our research grants. The researchers we have funded have published nearly 200 papers, which have been cited over 10,300 times. The work reflected in these papers has helped us to better understand Alzheimer’s and find ways to intervene that may lead to slowing or reversing the disease. We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate them for the important work they are doing. We also are grateful to our donors, who have made this work possible. Without your support and generosity, these papers and the forward momentum they represent would not exist.

2017

Yang Shi, Kaoru Yamada, Shane Antony Liddelow, Scott T. Smith, Lingzhi Zhao, Wenjie Luo, Richard M. Tsai, Salvatore Spina, Lea T. Grinberg, Julio C. Rojas, Gilbert Gallardo, Kairuo Wang, Joseph Roh, Grace Robinson, Mary Beth Finn, Hong Jiang, Patrick M. Sullivan, Caroline Baufeld, Michael W. Wood, Courtney Sutphen, Lena McCue, Chengjie Xiong, Jorge L. Del-Aguila, John C. Morris, Carlos Cruchaga, Alzheimer’s Disease Neuroimaging Initiative, Anne M. Fagan, Bruce L. Miller, Adam L. Boxer, William W. Seeley, Oleg Butovsky, Ben A. Barres, Steven M. Paul, David M. Holtzman, ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy, Nature, 20 Sep 2017
Daniel G. Abernathy, Woo Kyung Kim, Matthew J. McCoy, Allison M. Lake, Rebecca Ouwenga, Seong Won Lee, Xiaoyun Xing, Daofeng Li, Hyung Joo Lee, Robert O. Heuckeroth, Joseph D. Dougherty, Ting Wang, Andrew S. Yoo, MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts, Cell Stem Cell, 21(3), 7 Sep 2017, 332-348
Myles R. Minter, Reinhard Hinterleitner, Marlies Meisel, Can Zhang, Vanessa Leone, Xiaoqiong Zhang, Paul Oyler-Castrillo, Xulun Zhang, Mark W. Musch, Xunuo Shen, Bana Jabri, Eugene B. Change, Rudolph E. Tanzi, Sangram Sisodia, Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP(SWE)/PS1(Delta E9) murine model of Alzheimer's disease, Scientific Reports, 7, 5 Sep 2017
Hyung Jin Ahn, Zu-Lin Chen, Daria Zamolodchikov, Erin H. Norris, Sidney Strickland, Interactions of beta-amyloid peptide with fibrinogen and coagulation factor XII may contribute to Alzheimer's disease, Current Opinion In Hematology, 24(5), 1 Sep 2017, 427-431
Norelle C. Wildburger, Thomas J. Esparza, Richard D. LeDuc, Ryan T. Fellers, Paul M. Thomas, Nigel J. Cairns, Neil L. Kelleher, Randall J. Bateman, David L. Brody, Diversity of Amyloid-beta Proteoforms in the Alzheimer's Disease Brain, Scientific Reports, 7, 25 Aug 2017
David L. Brody, Hao Jiang, Norelle Wildburger, Thomas J. Esparza, Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer's disease, Alzheimers Research & Therapy, 9(1), 17 Aug 2017, 62
Tyler K. Ulland, Wilbur M. Song, 7, Stanley Ching-Cheng Huang, Jason D. Ulrich, Alexey Sergushichev, Wandy L. Beatty, Alexander A. Loboda, Yingyue Zhou, Nigel J. Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W. Virgin, Emil R. Unanue, Yaming Wang, Maxim N. Artyomov, David M. Holtzman, Marco Colonna, TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease, Cell, 170(4), 10 Aug 2017, 649–663
Vitaliy Ovod, Kara N. Ramsey, Kwasi G. Mawuenyega, Jim G. Bollinger, Terry Hicks, Theresa Schneider, Melissa Sullivan, Katrina Paumier, David M. Holtzman, John C. Morris, Tammie Benzinger, Anne M. Fagan, Bruce W. Patterson, Randall J. Bateman, Amyloid beta concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis, Alzheimers & Dementia, 13(8), Aug 2017, 841-849
Dragan Gamberger, Nada Lavrač, Shantanu Srivatsa, Rudolph E. Tanzi, P. Murali Doraiswamy, Identification of clusters of rapid and slow decliners among subjects at risk for Alzheimer's disease, Scientific Reports, 7, 28 Jul 2017
Feng Liang, Yu Wan, Diane Schaak, Joseph Ward, Xunuo Shen, Rudolph E. Tanzi, Can Zhang, Qimin Quan, Nanoplasmonic fiber tip probe detects significant reduction of intracellular Alzheimer's diseaserelated oligomers by curcumin, Scientific Reports, 7, 18 Jul 2017
Jing Zhao, Mary D. Davis, Yuka A. Martens, Mitsuru Shinohara, Neill R. Graff-Radford, Steven G. Younkin, Zbigniew K. Wszolek, Takahisa Kanekiyo, Guojun Bu, APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes, Human Molecular Genetics, 26(14), 15 Jul 2017, 2690-2700
Lies Schoonaert, Laura Rue, Bart Roucourt, Mieke Timmers, Susan Little, Lucia Chavez-Gutierrez, Maarten Dewilde, Peter Joyce, Adam Curnock, Peter Weber, Jurgen Haustraete, Gholamreza Hassanzadeh-Ghassabeh, Bart De Strooper, Ludo Van den Bosch, Philip Van Damme, Robin Lemmens, Wim Robberecht, Identification and characterization of Nanobodies targeting the EphA4 receptor, Journal Of Biological Chemistry, 292(27), 7 Jul 2017, 11452-11465
Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez‐Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haass, The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism, Embo Journal, 36(13), 3 Jul 2017, 1837-1853
Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee, Corinne M. Echmalian, Weiming Xia, Luisa Quinti, Graham Johnson, Jiunn H. Lin, Doo Y. Kim, William C. Mobley, Robert A. Rissman, Rudolph E. Tanzi, Pharmacological and Toxicological Properties of the Potent Oral gamma-Secretase Modulator BPN-15606, Journal Of Pharmacology And Experimental Therapeutics, 362(1), Jul 2017, 31-44
Mitsuru Shinohara, Masaya Tachibana, Takahisa Kanekiyo, Guojun Bu, Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies, Journal Of Lipid Research, 58(7), Jul 2017, 1267-1281
Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao-Fen Chen, TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway, Frontiers In Aging Neuroscience, 9, 21 Jun 2017, 204
Hyoung Tae Kim, Alfred L. Goldberg, The deubiquitinating enzyme Usp14 allosterically inhibits multiple proteasomal activities and ubiquitin-independent proteolysis, Journal Of Biological Chemistry, 292(23), 9 Jun 2017, 9830-9839
Sarah K. Kaufman, Talitha L. Thomas, Kelly Del Tredici, Heiko Braak, Marc I. Diamond, Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue, Acta Neuropathologica Communications, 5, 7 Jun 2017, 41
Nir Grossman, David Bono, Nina Dedic, Suhasa B. Kodandaramaiah, Andrii Rudenko, Ho-Jun Suk, Antonino M. Cassara, Esra Neufeld, Niels Kuster, Li-Huei Tsai, Alvaro Pascual-Leone, Edward S. Boyden, Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields, Cell, 169(6), 1 Jun 2017, 1029-1041
Evan P. Lebois, Jason P. Schroeder, Thomas J. Esparza, Thomas M. Bridges, Craig W. Lindsley, P. Jeffrey Conn, David L. Brody, J. Scott Daniels, Allan I. Levey, Disease-Modifying Effects of M-1 Muscarinic Acetylcholine Receptor Activation in an Alzheimer's Disease Mouse Model, Acs Chemical Neuroscience, 8(6), Jun 2017, 1177-1187
Galen Andrew Collins, Alfred L. Goldberg, The Logic of the 26S Proteasome, Cell, 169(5), 18 May 2017, 792-806
Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass, TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury, EMBO Reports, 8 May 2017
Zu-Lin Chen, Alexey S. Revenko, Pradeep Singh, A. Robert MacLeod, Erin H. Norris, Sidney Strickland, Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice, Blood, 129(18), 4 May 2017, 2547-2556
Justin T. Rogers, Chia-Chen Liu, Na Zhao, Jian Wang, Travis Putzke, Longyu Yang, Mitsuru Shinohara, John D. Fryer, Takahisa Kanekiyo, Guojun Bu, Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging, 53, May 2017, 112-121
Jason D. Ulrich, Tyler K. Ulland, Marco Colonna, and David M. Holtzman, Elucidating the Role of TREM2 in Alzheimer’s Disease, Neuron, 94, 19 Apr 2017, 237-248
Paul Temkin, Wade Morishita, Debanjan Goswami, Kristin Arendt, Lu Chen, Robert Malenka, The Retromer Supports AMPA Receptor Trafficking During LTP, Neuron, 94(1), 5 Apr 2017, 74–82
Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph E. Tanzi, Marco Colonna, Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 13(4), Apr 2017, 381–387
L Ashley Watson, Li-Huei Tsai, In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology, 43, April 2017, 48-55
Bevan S. Main, Myles R. Minter, Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience, 11, 23 Mar 2017, 151
Heide Loehlein Fier, Dmitry Prokopenko, Julian Hecker, Michael H. Cho, Edwin K. Silverman, Scott T. Weiss, Rudolph E. Tanzi, Christoph Lange, On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology, 41(4), 20 Mar 2017, 332–340
Jerrah K. Holth, Thomas E. Mahan, Grace O. Robinson, Andreia Rocha, David M. Holtzman, Altered sleep and EEG power in the P301S Tau transgenic mouse model, Ann Clin Transl Neurol, 4(3), 15 Feb 2017, 180-190
William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos, Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage, PNAS, 114(6), 7 Feb 2017, 1389–1394
Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S. Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W. Mandell, George S. Bloom, mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease, Alzheimer's & Dementia, 13(2), Feb 2017, 152-167
Randolph M. Nesse, Caleb E. Finch, and Charles L. Nunn, Does selection for short sleep duration explain human vulnerability to Alzheimer’s disease?, Evol Med Public Health, 2017(1), 24 Jan 2017, 39-46
Dylan Kwart, Dominik Paquet, Shaun Teo and Marc Tessier-Lavigne, Precise and efficient scarless genome editing in stem cells using CORRECT, Nature Protocols, 12, 19 Jan 2017, 329–354
Pierre De Rossi, Virginie Buggia-Prevot, Robert J Andrew, Sofia V Krause, Elizabeth Woo, Peter T Nelson, Peter Pytel, Gopal Thinakaran, BIN1 localization is distinct from Tau tangles in Alzheimer’s disease, Matters, 12 Jan 2017
S. Veugelen, M. Dewilde, B. De Strooper, L. Chávez-Gutiérrez, Chapter Three - Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins, Methods in Enzymology, 584, 2017, 59–97
Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo, The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 6, 2017, 50-59

2016

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, John C. Morris, Ronald C. Petersen, Jennifer Salazar, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, John Q. Trojanowski, The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement, Alzheimer's & Dementia, 5 Dec 2016
Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monté, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo, Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease, Alzheimer's & Dementia, 12(12), Dec 2016, 1259–1272
Nina Fainstein, Dvir Dori, Kati Frid, Alexa T. Fritz, Ilona Shapiro, Ruth Gabizon, and Tamir Ben-Hur, Chronic Progressive Neurodegeneration in a Transgenic Mouse Model of Prion Disease, Frontiers in Neuroscience, 10, 11 Nov 2016
Rebecca G. Canter, Jay Penney, and Li-Huei Tsai, The road to restoring neural circuits for the treatment of Alzheimer's disease, Nature, 539(7628), 10 Nov 2016, 187–196
Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS, mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease, Alzheimer's & Dementia, 29 Sep 2016
Han-Kyu Lee, Clara Velazquez Sanchez, Mei Chen, Peter J. Morin, John M. Wells, Eugene B. Hanlon, Weiming Xia, Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells, PLOS ONE, 11(9), 29 September 2016
Deepak Kumar Vijaya Kumar , William A Eimer , Rudolph E Tanzi and Robert D Moir, Alzheimer’s disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide, Neurodegenerative Disease Management, 6(5), 7 Sep 2016, 345–348
Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass, TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance, EMBO Molecular Medicine, 8(9), 1 Sep 2016, 987-1113
Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph Tanzi, Marco Colonna, Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 9 Aug 2016
Henry H. Ruiz, Tiffany Chi, Andrew C. Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettner, Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels, Alzheimer's & Dementia, 12(8), Aug 2016, 851–861
Elysse M. Knight, PhD, Soong Ho Kim, PhD, Jessica C. Kottwitz, BS, Asa Hatami, PhD, Ricardo Albay, BS, Akinobu Suzuki, PhD, Alex Lublin, PhD, Cristina M. Alberini, PhD, William L. Klein, PhD, Paul Szabo, PhD, Norman R. Relkin, MD, PhD, Michelle Ehrlich, MD, Charles G. Glabe, PhD, Sam Gandy, MD, PhD and John W. Steele, PhD, Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes, Neurol Neuroimmunol Neuroinflamm, 3(3), May 2016
Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin, Interaction of tau with the RNA-binding Protein TIA1 Regulates tau Pathophysiology and Toxicity, Cell Reports, May 2016