Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers that result from Cure Alzheimer’s Fund support. Most of the papers grow out of the Alzheimer’s Genome Project™ (AGP), as that is where most of our investment has gone. The AGP has met its goal of identifying most of the remaining genes that affect risk or provide protection from Alzheimer’s disease in three years for about $3 million. Some 70 genes have been newly identified and now are available for follow up by Cure Alzheimer’s Fund-supported researchers and others. The other papers represent innovative and in most cases collaborative investigations of more “translational” research–research enabled by the discovery of the first four genes that have been known to the field for some time. These papers point to ways for potentially faster development of therapies that affect the disease mechanism, not just the symptoms. We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate all of them for the important work reflected in these papers. We also are grateful to all of those who literally made this work possible. Without those of you who have supported Cure Alzheimer’s Fund projects through your generosity, these papers and the momentum forward they represent would not exist.

2015

Dara L. Dickstein, Effie M. Mitsis, Corey Fernandez, Mariel Pullman, Patrick R. Hof, Jennifer Short, Gregory Elder, Barry Jordan, Stephen Ahlers, Heidi Bender, Martin L. Goldstein, John F. Crary, Kristen Dams-O’Connor, Wayne Gordon, Robert Cantu, Karin Knesaurek, Mary Sano, James R. Stone6, Lale Kostakoglu, Steven T. DeKosky, and Sam Gandy, Chronic Traumatic Encephalopathy: Diagnosing the Repetitively Injured Brains of Athletes and Soldiers, Current Research: Concussion, December 2015
Joshua G Hunsberger, Ph.D., Mahendra Rao, M.D., Joanne Kurtzberg, M.D., Jeff W. M. Bulte, Ph.D., Anthony Atala, M.D., Frank M. LaFerla, Ph.D., Henry T. Greely, J.D., Akira Sawa, M.D., Sam Gandy, M.D., Lon S. Schneider, M.D., P. Murali Doraiswamy, M.B.B.S., Accelerating stem cell trials for Alzheimer's disease, The Lancet Neurology, 15 December 2015
Christina M. Lill, Aina Rengmark, Lasse Pihlstrøm, Isabella Fogh, Aleksey Shatunov, Patrick M. Sleiman, Li-San Wang, Tian Liu, Christina F. Lassen, Esther Meissner, Panos Alexopoulos, Andrea Calvo, Adriano Chio, Nil Dizdar, Frank Faltraco, Lars Forsgren, Julia Kirchheiner, Alexander Kurz, Jan P. Larsen, Maria Liebsch, Jan Linder, Karen E. Morrison, Hans Nissbrandt, Markus Otto, Jens Pahnke, Amanda Partch, Gabriella Restagno, Dan Rujescu, Cathrin Schnack, Christopher E. Shaw, Pamela J. Shaw, Hayrettin Tumani, Ole-Bjørn Tysnes, Otto Valladares, Vincenzo Silani, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Ulman Lindenberger, Elisabeth Steinhagen-Thiessen, Stefan Teipel, Robert Perneczky, Hakon Hakonarson, Harald Hampel, Christine A.F. von Arnim, Jørgen H. Olsen, Vivianna M. Van Deerlin, Ammar Al-Chalabi, Mathias Toft, Beate Ritz, Lars Bertram, The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease, Alzheimer's & Dementia, 11(12), December 2015, 1407–1416
Hannah Brautigam, Cesar L. Moreno, John W. Steele, Alexey Bogush, Dara L. Dickstein, John B.J. Kwok, Peter R. Schofield, Gopal Thinakaran, Paul M. Mathews, Patrick R. Hof, Sam Gandy, and Michelle E. Ehrlich, Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin, Scientific Reports, 5, 2015, 17042
B Readhead, J-V Haure-Mirande, B Zhang, V Haroutunian, S Gandy, EE Schadt, JT Dudley, and ME Ehrlich, Molecular systems evaluation of oligomerogenic APPE693Q and fibrillogenic APPKM670/671NL/PSEN1Δexon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology, Molecular Psychiatry, November 2015, 1-13
Sam Gandy, Mary Sano, Alzheimer disease: Solanezumab—prospects for meaningful interventions in AD?, Nature Reviews Neurology, 11, 03 November 2015, 669–670
C. Ising, M. Stanley and D.M. Holtzman, Current thinking on the mechanistic basis of Alzheimer's and implications for drug development, Clinical Pharmacology & Therapeutics, 98(5), November 2015, 469–471
Jee Hoon Roh and David M. Holtzman, Is there a link between the sleep–wake cycle and Alzheimer's pathology?, Future Neurology, 10(3), 2015, 183-186
Carla D'Avanzo, Jenna Aronson, Young Hye Kim, Se Hoon Choi, Rudolph E. Tanzi and Doo Yeon Kim, Alzheimer's in 3D culture: Challenges and perspectives, BioEssays, 37(10), October 2015, 1139–1148
Octavian Adam, M.D., Christine L. Mac Donald, Ph.D., Dennis Rivet, M.D., John Ritter, M.D., Todd May, D.O., Maria Barefield, O.T.D., Josh Duckworth, M.D., Donald LaBarge, M.D., Dean Asher, M.D., Benjamin Drinkwine, M.D., Yvette Woods, Ph.D., Michael Connor, Psy.D. and David L. Brody, M.D., Ph.D., Clinical and imaging assessment of acute combat mild traumatic brain injury in Afghanistan, Neurology, 85(3), 21 July 2015, 219-227
Brendan P Lucey, David M Holtzman, How amyloid, sleep and memory connect, Nature Neuroscience , 18, June 25, 2015, 933–934
Dmitry Prokopenko , Julian Hecker, Edwin Silverman, Markus M. Nöthen, Matthias Schmid, Christoph Lange, Heide Loehlein Fier, Using Network Methodology to Infer Population Substructure, Plos, June 22, 2015
Virginie Buggia-Prévot, Gopal Thinakaran, Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons, BioEssays, 37(7), June 2015
Christina M. Lill MD, Johnni Hansen PhD, Jørgen H. Olsen MD, Harald Binder PhD, Beate Ritz MD, PhD and Lars Bertram MD, Impact of Parkinson's disease risk loci on age at onset, Movement Disorders, 30(6), May 2015, 847–850
Kiran Yanamandra, Hong Jiang, Thomas E. Mahan, Susan E. Maloney, David F. Wozniak, Marc I. Diamond and David M. Holtzman, Anti-tau antibody reduces insoluble tau and decreases brain atrophy, Annals of Clinical and Translational Neurology, 2(3), March 2015, 278–288
Connie Marras MD, PhD, Anthony Lang MD, Bart P. van de Warrenburg, Carolyn Sue, Sarah J. Tabrizi MBChB, PhD, Lars Bertram MD, Katja Lohmann PhD, Saadet Mercimek-Mahmutoglu MD, PhD, Alexandra Durr, Vladimir Kostic, Christine Klein MD, Recommendations of the International Parkinson and Movement Disorder Society Task Force on Nomenclature of Genetic Movement Disorders,

2014

Miranda M Lim, Jason R Gerstner. David M Holtzman, The sleep–wake cycle and Alzheimer's disease: what do we know?, Neurodegenerative Disease Management, Vol. 4, No. 5, 351-362
H. Wang, Y. Dong, J. Zhang, Z. Xu, G. Wang, C. A. Swain, Y. Zhang and Z. Xie, Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors, Br. J. Anaesth.
Riqiang Yan, Robert Vassar, Targeting the β secretase BACE1 for Alzheimer's disease therapy, The Lancet Neurology, 13(3), March 2014, 319 - 329
Zhongcong Xie, Celeste A. Swain, Sarah A. P. Ward, Hui Zheng, Yuanlin Dong, Neelakantan Sunder, Dennis W. Burke, Diana Escobar, Yiying Zhang and Edward R. Marcantonio, Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium, Annals of Clinical and Translational Neurology, 9 April 2014
Andrew A. Sproul, Samson Jacob, Deborah Pre, Soong Ho Kim, Michael W. Nestor, Miriam Navarro-Sobrino, Ismael Santa-Maria, Matthew Zimmer, Soline Aubry, John W. Steele, David J. Kahler, Alex Dranovsky, Ottavio Arancio, John F. Crary, Sam Gandy, and Scott A. Noggle, Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors, PLoS ONE, 9(1), Jan 8 2014
(S38.002) Lucas Restrepo, Phillip Stafford and Stephen Johnston, High Accuracy of a Microarray-Based Blood Test for Alzheimer’s Disease (S38.002), Neurology, 82(10), April 8, 2014
Christina M. Lill, Marcel Schilling, Sara Ansaloni, Julia Schröder, Marian Jaedicke, Felix Luessi, Brit-Maren M. Schjeide, Andriy Mashychev, Christiane Graetz, Denis A. Akkad, Lisa-Ann Gerdes, Antje Kroner, Paul Blaschke, Sabine Hoffjan, Alexander Winkelmann, Thomas Dörner, Peter Rieckmann, Elisabeth Steinhagen-Thiessen, Ulman Lindenberger, Andrew Chan, Hans-Peter Hartung, Orhan Aktas, Peter Lohse, Mathias Buttmann, Tania Kümpfel, Christian Kubisch, Uwe K. Zettl, Joerg T. Epplen, Frauke Zipp, Lars Bertram, Assessment of microRNA-related SNP effects in the 3′ untranslated region of theIL22RA2 risk locus in multiple sclerosis, Neurogenetics, 15(2), March 18 2014, 129-134
David Cantu, Kendall Walker, Lauren Andresen, Amaro Taylor-Weiner, David Hampton, Giuseppina Tesco and Chris G. Dulla, Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control, Cereb. Cortex, March 7, 2014
Karthikeyan Veeraraghavalu, Can Zhang, Xiaoqiong Zhang, Rudolph E. Tanzi, and Sangram S. Sisodia, Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons, J Neurosci, 34(10), 5 March 2014, 3668-3673
Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z, Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Sci Rep, 4, January 20, 2014, 3766

2013

Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi, ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function, Neuron, 80(2), Oct 16, 2013, 385–401
Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G, A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease, PLOS ONE, 8(11), November 13, 2013
Klunk WE, Perani D, Amyloid and neurodegeneration: converging and diverging paths, Neurology, 81(20), November 12, 2013, 1728-1729
Zhang X, Xin X, Dong Y, Zhang Y, Yu B, Mao J, Xie Z, Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice, J Neurosci, 33(45), November 6, 2013, 17737-17748
Hughes TM, Kuller LH, Barinas-Mitchell EJ, Mackey RH, McDade EM, Klunk WE, Aizenstein HJ, Cohen AD, Snitz BE, Mathis CA, Dekosky ST, Lopez OL, Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults, Neurology, 81(19), November 5, 2013, 1711-1718
Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC, Clinical presentation of chronic traumatic encephalopathy, Neurology, 81(13), September 24, 2013, 1122-1129
Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE, Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography, Hum Mol Genet, 22(18), September 15, 2013, 3798-3806
Rudolph E Tanzi, Decoding Alzheimer's in the age of genome-wide analyses, Mol Neurodegener, 8(suppl 1), September 13. 2013, 01
Vos SJ, Xiong C, Visser PJ, Jasielec MS, Hassenstab J, Grant EA, Cairns NJ, Morris JC, Holtzman DM, Fagan AM, Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study, The Lancet Neurology, 12(10), September 4, 2013, 957-965
J W Steele, M L Lachenmayer, S Ju, A Stock, J Liken, S H Kim, L M Delgado, I E Alfaro, S Bernales, G Verdile, P Bharadwaj, V Gupta, R Barr, A Friss, G Dolios, R Wang, D Ringe, P Fraser, D Westaway, P H St George-Hyslop, P Szabo, N R Relkin, J D Buxbaum, C G Glabe, A A Protter, R N Martins, M E Ehrlich, G A Petsko, Z Yue and S Gandy, Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model, Mol Psychiatry, 18(8), Aug 2013, 889-897
Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S, Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain, Mol Psychiatry, 18(8), August 2013, 882-888
Walker KR, Tesco G, Molecular mechanisms of cognitive dysfunction following traumatic brain injury, Front Aging Neurosci, 5(29), July 9, 2013
Raja Bhattacharyya, Cory Barren, Dora M. Kovacs, Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts, The Journal of Neuroscience, 33(27), 3 July 2013, 11169-83
BV Hooli1, ZM Kovacs-Vajna2, K Mullin1, MA Blumenthal1, M Mattheisen3, C Zhang1, C Lange4, G Mohapatra5, L Bertram6 and RE Tanzi1, Rare autosomal copy number variations in early-onset familial Alzheimer’s disease, Molecular Psychology, 6/11/2013
Zhongcong Xie, MD, PhD, Sayre McAuliffe, Celeste A. Swain, Sarah A. P. Ward, Catherine A. Crosby, Hui Zheng, Janet Sherman, Yuanlin Dong, Yiying Zhang, Neelakantan Sunder, Dennis Burke, Kevin Washicosky, Rudolph E. Tanzi, and Edward R. Marcantonio, Cerebrospinal Fluid Aβ to Tau Ratio and Postoperative Cognitive Change, Annals of Surgery, Ann Surg 2013;00 , 5/10/2013, 1-6
International Multiple Sclerosis Genetics Consortium, Lill CM, Schjeide BM, Graetz C, Ban M, Alcina A, Ortiz MA, Pérez J, Damotte V, Booth D, Lopez de Lapuente A, Broer L, Schilling M, Akkad DA, Aktas O, Alloza I, Antigüedad A, Arroyo R, Blaschke P, Buttmann M, Chan A, Compston A, Cournu-Rebeix I, Dörner T, Epplen JT, Fernández Ó, Gerdes LA, Guillot-Noël L, Hartung HP, Hoffjan S, Izquierdo G, Kemppinen A, Kroner A, Kubisch C, Kümpfel T, Li SC, Lindenberger U, Lohse P, Lubetzki C, Luessi F, Malhotra S, Mescheriakova J, Montalban X, Papeix C, Paredes LF, Rieckmann P, Steinhagen-Thiessen E, Winkelmann A, Zettl UK, Hintzen R, Vandenbroeck K, Stewart G, Fontaine B, Comabella M, Urcelay E, Matesanz F, Sawcer S, Bertram L, Zipp F, MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis, Brain, 1386 (Pt 6), June 2013, 1778-1782
Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY, BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels, FASEB J, 27(6), June 2013, 2458-67
Irene Pichler, Fabiola Del Greco M., Martin Gögele, Christina M. Lill, Lars Bertram, Chuong B. Do, Nicholas Eriksson, Tatiana Foroud, Richard H. Myers, PD GWAS Consortium, Michael Nalls, Margaux F. Keller, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium, Beben Benyamin, John B. Whitfield, Genetics of Iron Status Consortium, Peter P. Pramstaller, Andrew A. Hicks, John R. Thompson, and Cosetta Minelli, Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study, PLOS Med , 10(6), June 2013
Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr, Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, Br. J. Anaesth. , 111(2), May 30, 2013, 143-151
Zhang L, Zhang J, Yang L, Dong Y, Zhang Y, Xie Z, Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia, April 19, 2013
Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S, Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-β Peptide, J Neurosci, 33(16), April 17, 2013, 7099-7107
Steven T. DeKosky, Kaj Blennow, Milos D. Ikonomovic & Sam Gandy, Traumatic Brain Injury (TBI) can lead to Neurodegenerative Syndromes that include Alzheimer Disease (AD) and Chronic Traumatic Encephalopathy (CTE), Nature Reviews Neurology, Volume 9, No 4 , April 2013, 192-200