Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers that result from Cure Alzheimer’s Fund support.

Most of the papers grow out of the Alzheimer’s Genome Project (AGP) as that is where most of our investment has gone. The AGP has met its goal of identifying most of the remaining genes that affect risk or provide protection from Alzheimer’s disease in three years for about $3 million. 70 genes have been newly identified and are now available for follow-up by Cure Alzheimer’s Fund supported researchers and others.

The other papers represent innovative and in most cases collaborative investigations of more “translational” research --- research enabled by the discovery of the first four genes which have been known to the field for some time. These papers point to ways for potentially faster development of therapies that affect the disease mechanism, not just the symptoms.

We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate all of them for the important work reflected in these papers. We are also grateful to all of those who literally made this work possible. Without those of you who have supported Cure Alzheimer’s Fund projects through your generosity, these papers and the momentum forward they represent would not exist.

2011

Kang JE, Cirrito JR, Dong H, Csernansky JG, Holtzman DM. "Expand Acute stress increases interstitial fluid amyloid-β via corticotropin-releasing factor and neuronal activity."
Zhang Y-w, Liu Shijie, Zhang X, Li W-B, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen S, Greengard P, Liao F-F, Li L, Xu H. "A Functional Mouse Retroposed Gene Rps23r1 Reduces Alzheimer's β-Amyloid Levels and Tau Phosphorylation."
Hu WT, McMillan C, Libon D, Leight S, Forman M, Lee VM-Y, Trojanowski JQ, Grossman M. "Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia."
Viswanathan J, Haapasalo A, Bottcher C, Miettinen R, Kurkinen KMA, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Nertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. "Alzheimer's Disease-Associated Ubiquilin-1 Regulates Presenilin-1 Accumulation and Aggresome Formation." Traffic

2010

Schwetye KE, Cirrito JR, Esparza TJ, Mac Donald CL, Holtzman DM, Brody DL. "Traumatic brain injury reduces soluble extracellular amyloid-β in mice: A methodologically novel combined microdialysis-controlled cortical impact study." Neurobiology of Disease Volume 40, Issue 3 (Dec 2010) : 555-564.
Bertram L, Lill CM, Tanzi RE. "The Genetics of Alzheimer Disease: Back to the Future." Neuron Volume 68, Issue 2 : 270-281.
Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. "Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex." The Journal of Neuroscience 30(39) (Sep 29 2010) : 13110-13115.
Zhang C, Browne A, Child D, Tanzi RE. "Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein." The Journal of Biological Chemistry 285 : 28472-28480.
Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ. "Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice." Journal of Cerebral Blood Flow & Metabolism 31 (2011) : 351–361.
Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE. "Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome." PLoS ONE 5(5) e10659, 10.1371/journal.pone.0010659
Veeraraghavalu K, Choi SH, Zhang X, Sisodia SS. "Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling." The Journal of Neuroscience 30(20) (May 19 2010) : 6903-6915.
Gimbel DA, Nygaard HB, Coffey EE, Gunther EC, Lauren J, Gimbel ZA, Strittmatter SM. "Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein." The Journal of Neuroscience 30(18) (May 5 2010) : 6367-6374.
Kurup P, Zhang Y, Xu J, Venkitaramani DV, Haroutunian V, Greengard P, Nairn AC, Lombroso PJ. "Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP." The Journal of Neuroscience 30(17) (Apr 28 2010) : 5948-5957.
Kim SH, Fraser PE, Westaway D, George-Hyslop PH, Ehrlich ME, Gandy S. "Group II Metabotropic Glutamate Receptor Stimulation Triggers Production and Release of Alzheimer's Amyloid β42 from Isolated Intact Nerve Terminals." The Journal of Neuroscience 30(11) (Mar 17 2010) : 3870-3875.
Lublin AL, and Gandy S. "Amyloid-β Oligomers: Possible Role as Key Neurotoxins in Alzheimer's Disease.." Mount Sinai Joural of Medicine 77 (2010) : 1-7.
Zeng C, Pan F, Jones LA, Lim MM, Griffin EA, Sheline YI, Mintun MA, Holtzman DM, Mach RH. "Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system." Brain Research Volume 1319 (Mar 10 2010) : 21-32.
Gianni D, Li A, Tesco G, McKay KM, Moore J, Raygor K, Rota M, Gwathmey JK, Dec GW, Aretz T, Leri A, Semigran MJ, Anversa P, Macgillivray TE, Tanzi RE, delMonte F.. "Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy." Circulation: Journal of the American Heart Association
Sleegers K, Lambert J-C, Bertram L, Cruts M, Amouyel P, Broeckhoven CV. "The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects." Trends in Genetics Volume 26, Issue 2
Giedraitis V, Glaser A, Sarajarvi T, Brundin R, Gunnarsson MD, Schjeide B-M, Tanzi RE, Helisalmi S, Pirttila T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M. "CALHM1 P86L polymorphism does not alter amyloid-β or tau in cerebrospinal fluid." Neuroscience Letters Volume 469, Issue 2 (Jan 22 2010) : 265-267.
Zhang C, Browne A, Child D, DiVito JR, Stevenson JA, Tanzi RE. "Loss-of-Function of ATXN1 Increases Amyloid-Beta Levels by Potentiating Beta-Secretase Processing of APP.." Journal of Biological Chemistry
Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. "Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers." Annals of Neurology Volume 68, Issue 2 (2010)

2009

Wei W, Nguyen L, Kessels HW, Hagiwara H, Sisodia S, Malinow R. "Amyloid beta from axons and dendrites reduces local spine number and plasticity." Nature Neuroscience Volume 13 (2010) : 190-196.
Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins R, Yamamoto K, Maeda M, Yamamoto T, Nakaya T, Gandy S, Suzuki T. "Alcadein Cleavages by Amyloid -Precursor Protein (APP)- and -Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related -Secretase Dysfunction*." The Journal of Biological Chemistry 284 : 36024-36033.
Choi SH, Li Y, Parada LF, Sisodia SS. "Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF." Mol Neurodegener 4 (2009) : 52.
Steele JW, Kim HS, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PSG, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S.. "Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo.." Molecular Neurodegeneration
Won S, Bertram L, Becker D, Tanzi RE, Lange C.. "Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family - Based Association Tests." Journal of International Chinese Statistical Association
Kaufer D, Gandy S.. "APOEe4 and Bapineuzumab: Infusing Pharmacogenomics into Alzheimer Disease Therapeutics." Neurology
Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA. "The COPD genetic association compendium: a comprehensive online database of COPD genetic associations." Hum. Mol. Genet. 10.1093/hmg/ddp519 (2009)
Nygaard HB, Strittmatter SM,. "Cellular Prion Protein Mediates the Toxicity of β-Amyloid Oligomers." Archives of Neurology Vol.66 No.11
Silva S, Alacoque X, Fourcade O, Samii K, Marque P, Woods R, Mazziotta J, Chollet F, Loubinoux I. "Wakefulness and loss of awareness: Brain and brainstem interaction in the vegetative state." Neurology
Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM.. "Amyloid- Beta Dynamics are Regulated by Orexin and Sleep-Wake Cycle.." Science Express
Clifford DB, Fagan AM, Holtzman DM, Morris JC, Teshome M, Shah AR, Kauwe JSK. "CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease." Neurology
Yan P, Bero AW, Cirrito JR, Xiao Q, Hu X, Wang Y, Gonzales E, Holtzman DM, Lee J-M. "Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice." The Journal of Neuroscience 29(34) (Aug 26 2009) : 10706-10714.
Liao M-C, Ahmed M, Smith SO, Norstrand WEV. "Degradation of Amyloid β Protein by Purified Myelin Basic Protein." The Journal of Biological Chemistry 284 : 28917-28925.
Bertram, L, Tanzi RE. "Genome-wide association studies in Alzheimer's disease." Human Molecular Genetics Vol 18, Review Issue 2 (2009)
Cao C, Cirrito JR, Lin X, Wang L, Verges DK, Dickson A, Mamcarz M, Zhang C, Mori T, Arendash GW, Holtzman DM, Potter H. "Caffeine suppresses beta-amyloid levels in plasma and brain of Alzheimer's transgenic mice.." Journal of Alzheimer's disease (2009)
Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, tesco G, Elliot K, Wagner SL, Moir RD, Becker KD, Tanzi RE.. "Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate alpha-secretase activity.." Human Molecular Genetics Vol 18 (2009)
Hooli BV, Tanzi RE. "A current view of Alzheimer's disease." F1000 Biology Rep. 1 (2009) : 54.
Bertram L. "Alzheimer's Disease Genetics: Current Status and Future Perspectives." International Review of Neurobiology Vol. 84
Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z,. "The Common Inhalational Anesthetic Sevoflurane Induces Apoptosis and Increases β-Amyloid Protein Levels." Archives of Neurology Vol. 66 No. 5
Hoos MD, Ahmed M, Smith SO, Van Nostrand WE. "Myelin basic protein binds to and inhibits the fibrillar assembly of Aß42 in vitro.." Biochemistry 48 : 4720-4727.
Kayed, R., Pensalfini, A., Margol, L., Sokolov, Y., Sarsoza, F., Head, E., Hall, J., and Glabe, C.. "Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer.." J Biol Chem 284 : 4230-4237.
Schjeide BM, Hooli B, Parkinson M, Hogan MF, DiVito J, Mullin K, Blacker D, Tanzi RE, Bertram L. "GAB2 as an Alzheimer Disease Susceptibility Gene, Follow up of Genomewide Association Results." Arch Neurol 66 (Feb 2009) : 250 – 254.
Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF. "Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides." Angewandte Chemi International Edition Volume 84 Issue 8

2008

Zhang C, Browne A, Kim DY, Tanzi RE. "Familial Alzheimer's Disease Mutations in Presenilin 1 Do Not Alter Levels of the Secretate Amyloid-Beta Protein Precursor Generated by Beta-Secretase Cleavage." Current Alzheimer Research 6 (2009)
Bertram L, Schjeide BM, Hooli B, Mullin K, Hiltunen M, Soininen H, Ingelsson M, Lannfelt L, Blacker D, Tanzi RE.. "No association between CALHM1 and Alzheimer's disease risk.." Cell. 135(6) (Dec 12 2008) : 993-4.
Schaffer B, Bertram L, Miller L, Mullin K, Weintraub S, Johnson N, Bigio E, Mesulam M, Wiedau-Pazos M, Jackson G, Cummings J, Cantor R, Levey A, Tanzi RE, and Geschwind D. . "Association of GSK3B with Alzheimer's Disease and Frontotemporal Dementia.." Arch. Neurol. 65(10) : 1368-1374.
Huttuner HJ, utter-Paier B, Barren C, Peach C, Havas D, Duller S, Xia W, Frosch MP, Windisch M, Kovacs DM.. "The ACAT Inhibitor CI-I0II Reverses Diffuse Brain Amyloid Pathology in Aged hAPP Mice.." Proceedings of the National Academy of Science (2008)
Bertram L, Lange CL, Mullin K, Parkinson M, Hsiao M, Hogan MF,  Schjeide BMM, Hooli B, DeVito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE.. "Genome-wide association analysis reveals novel Alzheimer’s disease susceptibility loci in addition to APOE.." Am. J. Hum. Genet. 83 (Oct 2008) : 623-632.
Cotton RG, Auerbach AD, Axton M, Barash CI, Berkovic SF, Brookes AJ, Burn J, Cutting G, den Dunnen JT, Flicek P, Freimer N, Greenblatt MS, Howard HJ, Katz M, Macrae FA, Maglott D, Möslein G, Povey S, Ramesar RS, Richards CS, Seminara D, Smith TD, Sobrido MJ, Solbakk JH, Tanzi RE, Tavtigian SV, Taylor GR, Utsunomiya J, Watson M. "The Human Variome Project." Science. 322(5903) (Nov 7 2008) : 861-2.
Glabe, C. G.. "Structural classification of toxic amyloid oligomers.." J Biol Chem 283 : 29639-29643.
Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. . "The common inhalation anesthetic isoflurane induces caspase activation and increases Ab level in vivo.." Annals of Neurology Volume 64 (Dec 2008)
Lagace D, Benavides D, Kansy J, Mapelli M, Greengard P, Bibb J, Eisch A. "Cdk5 is essential for adult hippocampal neurogenesis." Proceedings of the National Academy of Science Vol. 105 No. 47 (2008) : 18567-18571.
Brody DL, Holtzman DM. "Active and Passive Immunotherapy for Neurodegenerative Disorders." Annu Rev Neurosci. 31 (2008) : 175–193.
Schaffer B, Bertram L, Miller L, Mullin K, Weintraub S, Johnson N, Bigio E, Mesulam M, Wiedau-Pazos M, Jackson G, Cummings J, Cantor R, Levey A, Tanzi RE, and Geschwind D. . "Association of GSK3B with Alzheimer's Disease and Frontotemporal Dementia.." Archives Neurol. 65 (Oct 2008) : 1368-1374.
Bertram L, Tanzi RE. "Thirty Years of Alzheimer’s Disease Genetics: Systematic Meta-analyses Herald a New Era.." Nature Reviews Neurosci. (2008)
Kavvoura FK, McQueen MP, Khoury MJ, Tanzi RE, Bertram L, Ioannidis JPA.. "Evaluation of the potential excess of statistically significant findings reported genetic association studies: application to Alzheimer's disease." Am. J. Epidemiol. (2008)
Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, and Bertram L.. "Assessment of Alzheimer's disease case-control associations using family-based methods." Neurogenetics DOI 10.1007/s10048-008-1051-3, : 568-580.
Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS. "Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation." Neuron Volume 59, Issue 4
Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM.. "Amyloid-beta dynamics correlate with neurological status in the injured human brain.." Science (2008)
Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. "The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions.." J Biol Chem. 2;283(18) (2008) : 11866-75.
Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z.. "Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine.." J Neurosci 28 (2008) : 4551-60.
Berman DE, Dall’Armi C, Voronov SV, McIntire LBJ, Zhang H, Moore AZ, Staniszewski A, Arancio O, Kim T, Di Paolo G.. "Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4, 5-bisphosphate metabolism.." Nature Neuroscience (2008)

2007

Kayed, R., Head, E., Sarsoza, F., Saing, T., Cotman, C. W., Necula, M., Margol, L., Wu, J., Breydo, L., Thompson, J. L., et al. "Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers." Mol Neurodegener 2 : 1-11.
Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS. "Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin)." J Neurosci (26) (2007) : 7006-7010.
Tesco G, Koh YH, Kang E, Cameron A, Das S, Sena-Esteves M, Hiltunen, Yang S-H, Zhong Z, Shen Y, Simpkins J, Tanzi RE.. "Depletion of GGA3 stabilizes BACE and enhances ateb-secretase activity.." Neuron 54(5) (2007) : 721-37.
Cirrito JR, Kang J, Lee J, Stewart FR, Verges D, Silverio LM, Bu G, Mennerick S, Holtzman DM.. "Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo.." Neuron (2007)
Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. "Decreased catalytic activity of the insulin degrading enzyme in chromosome 10-linked Alzheimer’s disease families.." Journal of Biological Chemistry 282(11) (2007) : 7825-32.
Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE.. "The Inhalation Anaesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Aβ Accumulation.." J. Neurosci. 27 (2007) : 1247-1254.
McQueen MB, Bertram L, Lange C, Becker KD, Albert MS, Tanzi RE, Blacker D.. "Exploring Candidate Gene Associations with Neuropsychological Performance.." Am J Med Genet B Neuropsychiatr Genet 144(8) (2007) : 987-91.