Published Papers

Cure Alzheimer’s Fund is proud to present a list of published papers resulting from our research grants. The researchers we have funded have published nearly 200 papers, which have been cited over 10,300 times. The work reflected in these papers has helped us to better understand Alzheimer’s and find ways to intervene that may lead to slowing or reversing the disease. We thank all the researchers and lab personnel for their dedication and commitment to the common mission of ending this disease, and we congratulate them for the important work they are doing. We also are grateful to our donors, who have made this work possible. Without your support and generosity, these papers and the forward momentum they represent would not exist.

2017

Fargol Mazaheri, Nicolas Snaidero, Gernot Kleinberger, Charlotte Madore, Anna Daria, Georg Werner, Susanne Krasemann, Anja Capell, Dietrich Trümbach, Wolfgang Wurst, Bettina Brunner, Sebastian Bultmann, Sabina Tahirovic, Martin Kerschensteiner, Thomas Misgeld, Oleg Butovsky, Christian Haass, TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury, EMBO Reports, 8 May 2017
Justin T. Rogers, Chia-Chen Liu, Na Zhao, Jian Wang, Travis Putzke, Longyu Yang, Mitsuru Shinohara, John D. Fryer, Takahisa Kanekiyo, Guojun Bu, Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice, Neurobiology of Aging, 53, May 2017, 112-121
Jason D. Ulrich, Tyler K. Ulland, Marco Colonna, and David M. Holtzman, Elucidating the Role of TREM2 in Alzheimer’s Disease, Neuron, 94, 19 Apr 2017, 237-248
Paul Temkin, Wade Morishita, Debanjan Goswami, Kristin Arendt, Lu Chen, Robert Malenka, The Retromer Supports AMPA Receptor Trafficking During LTP, Neuron, 94(1), 5 Apr 2017, 74–82
L Ashley Watson, Li-Huei Tsai, In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory, Current Opinion in Neurobiology, 43, April 2017, 48-55
Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph E. Tanzi, Marco Colonna, Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 13(4), Apr 2017, 381–387
Bevan S. Main, Myles R. Minter, Microbial Immuno-Communication in Neurodegenerative Diseases, Frontiers in Neuroscience, 11, 23 Mar 2017, 151
Heide Loehlein Fier, Dmitry Prokopenko, Julian Hecker, Michael H. Cho, Edwin K. Silverman, Scott T. Weiss, Rudolph E. Tanzi, Christoph Lange, On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows, Genetic Epidemiology, 41(4), 20 Mar 2017, 332–340
Jerrah K. Holth, Thomas E. Mahan, Grace O. Robinson, Andreia Rocha, David M. Holtzman, Altered sleep and EEG power in the P301S Tau transgenic mouse model, Ann Clin Transl Neurol, 4(3), 15 Feb 2017, 180-190
William J. Netzer, Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard, and Victor Bustos, Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage, PNAS, 114(6), 7 Feb 2017, 1389–1394
Andrés Norambuena, Horst Wallrabe, Lloyd McMahon, Antonia Silva, Eric Swanson, Shahzad S. Khan, Daniel Baerthlein, Erin Kodis, Salvatore Oddo, James W. Mandell, George S. Bloom, mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease, Alzheimer's & Dementia, 13(2), Feb 2017, 152-167
Randolph M. Nesse, Caleb E. Finch, and Charles L. Nunn, Does selection for short sleep duration explain human vulnerability to Alzheimer’s disease?, Evol Med Public Health, 2017(1), 24 Jan 2017, 39-46
Dylan Kwart, Dominik Paquet, Shaun Teo and Marc Tessier-Lavigne, Precise and efficient scarless genome editing in stem cells using CORRECT, Nature Protocols, 12, 19 Jan 2017, 329–354
Pierre De Rossi, Virginie Buggia-Prevot, Robert J Andrew, Sofia V Krause, Elizabeth Woo, Peter T Nelson, Peter Pytel, Gopal Thinakaran, BIN1 localization is distinct from Tau tangles in Alzheimer’s disease, Matters, 12 Jan 2017
S. Veugelen, M. Dewilde, B. De Strooper, L. Chávez-Gutiérrez, Chapter Three - Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins, Methods in Enzymology, 584, 2017, 59–97
Juan Domingo Gispert, Gemma C. Monté, Marc Suárez-Calvet, Carles Falcon, Alan Tucholka, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo, The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2, Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 6, 2017, 50-59

2016

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Robert C. Green, Danielle Harvey, Clifford R. Jack Jr., William Jagust, John C. Morris, Ronald C. Petersen, Jennifer Salazar, Andrew J. Saykin, Leslie M. Shaw, Arthur W. Toga, John Q. Trojanowski, The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement, Alzheimer's & Dementia, 5 Dec 2016
Juan Domingo Gispert, Marc Suárez-Calvet, Gemma C. Monté, Alan Tucholka, Carles Falcon, Santiago Rojas, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Gernot Kleinberger, Christian Haass, José Luis Molinuevo, Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease, Alzheimer's & Dementia, 12(12), Dec 2016, 1259–1272
Nina Fainstein, Dvir Dori, Kati Frid, Alexa T. Fritz, Ilona Shapiro, Ruth Gabizon, and Tamir Ben-Hur, Chronic Progressive Neurodegeneration in a Transgenic Mouse Model of Prion Disease, Frontiers in Neuroscience, 10, 11 Nov 2016
Rebecca G. Canter, Jay Penney, and Li-Huei Tsai, The road to restoring neural circuits for the treatment of Alzheimer's disease, Nature, 539(7628), 10 Nov 2016, 187–196
Han-Kyu Lee, Clara Velazquez Sanchez, Mei Chen, Peter J. Morin, John M. Wells, Eugene B. Hanlon, Weiming Xia, Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells, PLOS ONE, 11(9), 29 September 2016
Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS, mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease, Alzheimer's & Dementia, 29 Sep 2016
Deepak Kumar Vijaya Kumar , William A Eimer , Rudolph E Tanzi and Robert D Moir, Alzheimer’s disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide, Neurodegenerative Disease Management, 6(5), 7 Sep 2016, 345–348
Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass, TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance, EMBO Molecular Medicine, 8(9), 1 Sep 2016, 987-1113
Wilbur Song, Basavaraj Hooli, Kristina Mullin, Sheng Chih Jin, Marina Cella, Tyler K. Ulland, Yaming Wang, Rudolph Tanzi, Marco Colonna, Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation, Alzheimer's & Dementia, 9 Aug 2016
Henry H. Ruiz, Tiffany Chi, Andrew C. Shin, Claudia Lindtner, Wilson Hsieh, Michelle Ehrlich, Sam Gandy, Christoph Buettner, Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels, Alzheimer's & Dementia, 12(8), Aug 2016, 851–861
Elysse M. Knight, PhD, Soong Ho Kim, PhD, Jessica C. Kottwitz, BS, Asa Hatami, PhD, Ricardo Albay, BS, Akinobu Suzuki, PhD, Alex Lublin, PhD, Cristina M. Alberini, PhD, William L. Klein, PhD, Paul Szabo, PhD, Norman R. Relkin, MD, PhD, Michelle Ehrlich, MD, Charles G. Glabe, PhD, Sam Gandy, MD, PhD and John W. Steele, PhD, Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes, Neurol Neuroimmunol Neuroinflamm, 3(3), May 2016
Dominik Paquet, Dylan Kwart, Antonia Chen, Andrew Sproul, Samson Jacob, Shaun Teo, Kimberly Moore Olsen, Andrew Gregg, Scott Noggle and Marc Tessier-Lavigne, Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9, Nature, 533(7601), May 2016, 125-9
Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, Peter E.A. Ash, Casey Cook, Edroaldo Lummertz da Rocha, Karen Jansen-West, Alissa A. Frame, Allison Citro, John D. Leszyk, Pavel Ivanov, Jose F. Abisambra, Martin Steffen, Hu Li, Leonard Petrucelli, Benjamin Wolozin, Interaction of tau with the RNA-binding Protein TIA1 Regulates tau Pathophysiology and Toxicity, Cell Reports, May 2016
Daria Zamolodchikov, Sidney Strickland, A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease, Thrombosis Research, 141(2), May 2016, S59-S61
Nobutaka Sakae, Chia-Chen Liu, Mitsuru Shinohara, Jessica Frisch-Daiello, Li Ma, Yu Yamazaki, Masaya Tachibana, Linda Younkin, Aishe Kurti, Minerva M. Carrasquillo, Fanggeng Zou, Daniel Sevlever, Gina Bisceglio, Ming Gan, Romain Fol, Patrick Knight, Miao Wang, Xianlin Han, John D. Fryer, Michael L. Fitzgerald, Yasumasa Ohyagi, Steven G. Younkin, Guojun Bu, and Takahisa Kanekiyo, ABCA7 Deficiency Accelerates Amyloid- Generation and Alzheimer’s Neuronal Pathology, Neurobiology of Disease, 36(13), 30 Mar 2016, 3848–3859
Xulun Zhang, Eric Sullivan, Maggie Scimeca, Xianzhong Wu, Yue-ming Li and Sangram S. Sisodia, Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity, Journal of Biological Chemistry, 291(13), 25 Mar 2016, 6748-53
Mitsuru Shinohara, Takahisa Kanekiyo, Longyu Yang, Duane Linthicum, Motoko Shinohara, Yuan Fu, Laura Price, Jessica L. Frisch-Daiello, Xianlin Han, John D. Fryer, Guojun Bu, APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations, Annals of Neurology, 79(5), 2 Mar 2016, 758-774
Marc Suárez‐Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez‐Valle, Anna Antonell, Lorena Rami, José L Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass, sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers, EMBO Molecular Medicine, 8(3), March 2016, 173-303
Shahzad S. Khan and George S. Bloom, Tau: The Center of a Signaling Nexus in Alzheimer's Disease, Frontiers in Neuroscience, February 2016
C Herold, B V Hooli, K Mullin, T Liu, J T Roehr, M Mattheisen, A R Parrado, L Bertram, C Lange and R E Tanzi, Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer’s disease with OSBPL6, PTPRG, and PDCL3, Molecular Psychiatry, February 2016
Joshua G Hunsberger, PhD, Mahendra Rao, MD, Joanne Kurtzberg, MD, Jeff W M Bulte, PhD, Anthony Atala, MD, Frank M LaFerla, PhD, Henry T Greely, JD, Akira Sawa,MD, Sam Gandy, MD, Lon S Schneider, MD, P Murali Doraiswamy, MBBS, Accelerating stem cell trials for Alzheimer's disease, The Lancet Neurology, 15(2), February 2016, 219–230

2015

Dara L. Dickstein, Effie M. Mitsis, Corey Fernandez, Mariel Pullman, Patrick R. Hof, Jennifer Short, Gregory Elder, Barry Jordan, Stephen Ahlers, Heidi Bender, Martin L. Goldstein, John F. Crary, Kristen Dams-O’Connor, Wayne Gordon, Robert Cantu, Karin Knesaurek, Mary Sano, James R. Stone6, Lale Kostakoglu, Steven T. DeKosky, and Sam Gandy, Chronic Traumatic Encephalopathy: Diagnosing the Repetitively Injured Brains of Athletes and Soldiers, Current Research: Concussion, December 2015
Joshua G Hunsberger, Ph.D., Mahendra Rao, M.D., Joanne Kurtzberg, M.D., Jeff W. M. Bulte, Ph.D., Anthony Atala, M.D., Frank M. LaFerla, Ph.D., Henry T. Greely, J.D., Akira Sawa, M.D., Sam Gandy, M.D., Lon S. Schneider, M.D., P. Murali Doraiswamy, M.B.B.S., Accelerating stem cell trials for Alzheimer's disease, The Lancet Neurology, 15 December 2015
L. Schrewe, C. M. Lill, T. Liu, A. Salmen, L. A. Gerdes, L. Guillot-Noel, D. A. Akkad, P. Blaschke, C. Graetz, S. Hoffjan, A. Kroner, S. Demir, A. Böhme, P. Rieckmann, A. ElAli, N. Hagemann, D. M. Hermann, I. Cournu-Rebeix, F. Zipp, T. Kümpfel, M. Buttmann, U. K. Zettl, B. Fontaine, L. Bertram, R. Gold and A. Chan, Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS, Journal of Neuroinflammation, 12(1), December 2015, 1-7
Christina M. Lill, Aina Rengmark, Lasse Pihlstrøm, Isabella Fogh, Aleksey Shatunov, Patrick M. Sleiman, Li-San Wang, Tian Liu, Christina F. Lassen, Esther Meissner, Panos Alexopoulos, Andrea Calvo, Adriano Chio, Nil Dizdar, Frank Faltraco, Lars Forsgren, Julia Kirchheiner, Alexander Kurz, Jan P. Larsen, Maria Liebsch, Jan Linder, Karen E. Morrison, Hans Nissbrandt, Markus Otto, Jens Pahnke, Amanda Partch, Gabriella Restagno, Dan Rujescu, Cathrin Schnack, Christopher E. Shaw, Pamela J. Shaw, Hayrettin Tumani, Ole-Bjørn Tysnes, Otto Valladares, Vincenzo Silani, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Ulman Lindenberger, Elisabeth Steinhagen-Thiessen, Stefan Teipel, Robert Perneczky, Hakon Hakonarson, Harald Hampel, Christine A.F. von Arnim, Jørgen H. Olsen, Vivianna M. Van Deerlin, Ammar Al-Chalabi, Mathias Toft, Beate Ritz, Lars Bertram, The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease, Alzheimer's & Dementia, 11(12), December 2015, 1407–1416
Ezekiel Crenshaw, Brian P. Leung, Chun Kit Kwok, Michal Sharoni, Kalee Olson, Neeraj P. Sebastian, Sara Ansaloni, Reinhard Schweitzer-Stenner, Michael R. Akins, Philip C. Bevilacqua, Aleister J. Saunders, Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex, PLOS ONE, 10(11), Nov 2015
Hannah Brautigam, Cesar L. Moreno, John W. Steele, Alexey Bogush, Dara L. Dickstein, John B.J. Kwok, Peter R. Schofield, Gopal Thinakaran, Paul M. Mathews, Patrick R. Hof, Sam Gandy, and Michelle E. Ehrlich, Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1−/− phenotype and forms complexes with wildtype PS1 and nicastrin, Scientific Reports, 5, 2015, 17042
B Readhead, J-V Haure-Mirande, B Zhang, V Haroutunian, S Gandy, EE Schadt, JT Dudley, and ME Ehrlich, Molecular systems evaluation of oligomerogenic APPE693Q and fibrillogenic APPKM670/671NL/PSEN1Δexon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology, Molecular Psychiatry, November 2015, 1-13
Sam Gandy, Mary Sano, Alzheimer disease: Solanezumab—prospects for meaningful interventions in AD?, Nature Reviews Neurology, 11, 03 November 2015, 669–670
C. Ising, M. Stanley and D.M. Holtzman, Current thinking on the mechanistic basis of Alzheimer's and implications for drug development, Clinical Pharmacology & Therapeutics, 98(5), November 2015, 469–471
Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G, Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), The Journal of Biological Chemistry, 290(43), Oct 2015, 26043-50
Jee Hoon Roh and David M. Holtzman, Is there a link between the sleep–wake cycle and Alzheimer's pathology?, Future Neurology, 10(3), 2015, 183-186
Carla D'Avanzo, Jenna Aronson, Young Hye Kim, Se Hoon Choi, Rudolph E. Tanzi and Doo Yeon Kim, Alzheimer's in 3D culture: Challenges and perspectives, BioEssays, 37(10), October 2015, 1139–1148
Quan Ren, Mian Peng, Yuanlin Dong, Yiying Zhang, Ming Chen, Ning Yin, Edward R. Marcantonio, and Zhongcong Xie, Surgery plus anesthesia induces loss of attention in mice, Frontiers in Cellular Neuroscience, 9, September 2015, 346