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Investigation of Certain Properties of Mitochondria Membranes Related to AD

Funding year(s): 
2008
Funding to date: 
$200,000

While the mechanism of Aβ cytotoxicity remains contentious, evidence is accumulating that membrane permiabilization plays a key role in the pathological activity of the peptide. This study will focus on role of Aβ oligomerization in the Aβ-mediated disruption of lipid bilayers.