Zhongcong Xie, M.D., Ph.D.

Mass General Hospital/Harvard

Funded in 2011 for work on "Surgery-induced Brain Inflammation Interacting With Genetic Mutation-Induced Elevated A-beta, Leading to Memory Impairment"

Funded Research

Project Description Researchers Funding
General Anesthetics and Alzheimer’s Disease

The goal of this project is to test the hypothesis that desflurane is a safer anesthetic than isoflurane for AD patients in order to find safer anesthetics that won’t worsen AD symptoms.

2012
$100,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

H. Wang, Y. Dong, J. Zhang, Z. Xu, G. Wang, C. A. Swain, Y. Zhang and Z. Xie, Isoflurane induces endoplasmic reticulum stress and caspase activation through ryanodine receptors, Br. J. Anaesth.
Zhongcong Xie, Celeste A. Swain, Sarah A. P. Ward, Hui Zheng, Yuanlin Dong, Neelakantan Sunder, Dennis W. Burke, Diana Escobar, Yiying Zhang and Edward R. Marcantonio, Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium, Annals of Clinical and Translational Neurology, 9 April 2014
Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z, Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice, Sci Rep, 4, January 20, 2014, 3766
Zhang X, Xin X, Dong Y, Zhang Y, Yu B, Mao J, Xie Z, Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice, J Neurosci, 33(45), November 6, 2013, 17737-17748
Zhongcong Xie, MD, PhD, Sayre McAuliffe, Celeste A. Swain, Sarah A. P. Ward, Catherine A. Crosby, Hui Zheng, Janet Sherman, Yuanlin Dong, Yiying Zhang, Neelakantan Sunder, Dennis Burke, Kevin Washicosky, Rudolph E. Tanzi, and Edward R. Marcantonio, Cerebrospinal Fluid Aβ to Tau Ratio and Postoperative Cognitive Change, Annals of Surgery, Ann Surg 2013;00 , 5/10/2013, 1-6
Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr, Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar, Br. J. Anaesth. , 111(2), May 30, 2013, 143-151
Zhang L, Zhang J, Yang L, Dong Y, Zhang Y, Xie Z, Isoflurane and sevoflurane increase interleukin-6 levels through the nuclear factor-kappa B pathway in neuroglioma cells, British Journal of Anaesthesia, April 19, 2013
Shen X, Dong Y, Xu Z, Wang H, Miao C, Soriano SG, Sun D, Baxter MG, Zhang Y, Xie Z, Selective Anesthesia-induced Neuroinflammation in Developing Mouse Brain and Cognitive Impairment, Anesthesiology, Jan 9, 2013
Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z, Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons, Curr Mol Med., Sep 3, 2012
Xie Z, Xu Z, General anesthetics and β-amyloid protein, Prog Neuropsychopharmacol Biol Psychiatry, Aug 14, 2012, 140-146
Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z, The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β, Neurobiology of Aging, 33(7), July 2012, 1364-78
Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE, RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing, Transl Neurodegener., 1:8, Mar 22, 2012
Yiying Zhang MD, MS1, Zhipeng Xu MD, PhD1, Hui Wang MD1,2, Yuanlin Dong MD, MS1, Hai Ning Shi PhD, DVM3, Deborah J. Culley MD4, Gregory Crosby MD4, Edward R. Marcantonio MD5, Rudolph E. Tanzi PhD.6, Zhongcong Xie MD, PhD1,*, Anesthetics Isoflurane and Desflurane Differently Affect Mitochondrial Function, Learning, and Memory, Annals of Neurology, Volume 71, Issue 5, February 24, 2012, 687–698
Yuanlin Dong, Xu Wu, Zhipeng Xu, Yiying Zhang, Zhongcong Xie, Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation, PLoS One, 7(6), 2012
Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. , The common inhalation anesthetic isoflurane induces caspase activation and increases Aβ level in vivo., Annals of Neurology, Volume 64, Dec 2008
Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z, The inhalation anesthetic desflurane induces caspase activation and increases amyloid-beta protein levels under hypoxic conditions., J Biol Chem., 2;283(18), May 2, 2008, 11866-75
Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z., Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine., J Neurosci, 28, April 23, 2008, 4551-60
Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE., The Inhalation Anaesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Aβ Accumulation., J. Neurosci., 27, 2007, 1247-1254