Se Hoon Choi, Ph.D.

Headshot photo

Research Fellow in Neurology, Massachusetts General Hospital

Dr. Choi’s interest in Alzheimer’s disease (AD) began when he was a master’s degree student at Seoul National University College of Medicine. He studied toxic proteins causing AD, and developed anti-Alzheimer’s agents to ameliorate the symptoms of the disease. During his Ph.D. study at the University of Chicago, Dr. Choi expanded his interest to researching adult neurogenesis and genes causing familial cases of AD.  

He currently is working as a research fellow at Massachusetts General Hospital and Harvard Medical School. The goal of his current research is to explore adult neurogenesis as a therapeutic target for AD.

Funded Research

Project Description Researchers Funding
Exploring Adult Neurogenesis as a Therapeutic Target for Alzheimer's Disease

The goal of this project is to test whether the strategy of stimulating endogenous stem cells in the AD brain is safe in order to find treatment for Alzheimer’s patients.

Recent evidence shows the adult brain contains discrete populations of stem cells that retain the capacity to generate new neurons through the process of neurogenesis. Dr. Se Hoon Choi will test whether the strategy of stimulating endogenous stem cells in the AD brain is safe and effective ultimately to find treatment for Alzheimer’s patients.


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi, ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function, Neuron, 80(2), Oct 16, 2013, 385–401
Choi SH, Li Y, Parada LF, Sisodia SS, Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4, Dec 21, 2009, 52
Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF, Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides, Angewandte Chemi International Edition, Volume 48 Issue 8, February 9, 2009, 1487–1489
Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS, Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation, Neuron, Volume 59, Issue 4, August 28, 2008, 568-580
Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS, Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin), J Neurosci, (26), 2007, 7006-7010