Se Hoon Choi, Ph.D.

Instructor in Neurology, Massachusetts General Hospital

Dr. Choi’s interest in Alzheimer’s disease (AD) began when he was a master’s degree student at Seoul National University College of Medicine. He studied toxic proteins causing AD, and developed anti-AD agents to ameliorate the symptoms of the disease. During his Ph.D. study at the University of Chicago, Dr. Choi expanded his interest to researching adult neurogenesis in AD and genes causing familial cases of AD.  

He currently is working as an instructor at Massachusetts General Hospital and Harvard Medical School. The goal of his current CAF-funded research is to investigate the role of the blood-brain barrier in AD pathogenesis using a 3D microfluidic platform.  


Funded Research

Project Description Researchers Funding
Role of Blood-Brain Barrier Function in Alzheimer’s Disease Pathogenesis Investigated Using a 3-D Microfluidic Platform

Alzheimer’s disease (AD) is the most common form of dementia among older people. The blood-brain barrier (BBB) is a highly selective permeable barrier that separates the brain from circulating blood. It is formed by brain endothelial cells and prevents harmful materials from the blood from entering the brain. Evidence identifying BBB dysfunction in AD or patients at risk (i.e., those with mild cognitive impairment) continues to escalate.

Exploring Adult Neurogenesis as a Therapeutic Target for Alzheimer's Disease

The goal of this project is to test whether the strategy of stimulating endogenous stem cells in the AD brain is safe in order to find treatment for Alzheimer’s patients.

Recent evidence shows the adult brain contains discrete populations of stem cells that retain the capacity to generate new neurons through the process of neurogenesis. Dr. Se Hoon Choi will test whether the strategy of stimulating endogenous stem cells in the AD brain is safe and effective ultimately to find treatment for Alzheimer’s patients.


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Jaehong Suh, Se Hoon Choi, Donna M. Romano, Moira A. Gannon, Andrea N. Lesinski, Doo Yeon Kim, Rudolph E. Tanzi, ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function, Neuron, 80(2), Oct 16, 2013, 385–401
Choi SH, Li Y, Parada LF, Sisodia SS, Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF, Mol Neurodegener, 4, Dec 21, 2009, 52
Meier M, Kennedy-Darling J, Choi SH, Norstrom EM, Sisodia SS, Ismagilov RF, Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides, Angewandte Chemi International Edition, Volume 48 Issue 8, February 9, 2009, 1487–1489
Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS, Non-Cell-Autonomous Effects of Presenilin 1 Variants on Enrichment-Mediated Hippocampal Progenitor Cell Proliferation and Differentiation, Neuron, Volume 59, Issue 4, August 28, 2008, 568-580
Choi SH, Leight SN, Lee VM-Y, Li T, Wong PC, Johson JA, Saraiva MJ, Sisodia SS, Accelerated Aβ Deposition in APPswe/PS1∆E9 Mice with Hemizygous Deletions of TTR (Transthyretin), J Neurosci, (26), 2007, 7006-7010