Lee Goldstein, M.D., Ph.D.

Boston University


Currently funded for 2011 for his work on "Metallomic Mapping of the Aging Brain in the Trg2576 Transgenic Mouse Model".

Funded Research

Project Description Researchers Funding
Metallomic Mapping of the Aging Brain in Trg2576 Transgenic Mouse Model

The goal of this project is to perform the first high-resolution metallomic brain maps of key biometals (copper, zinc, iron) during normal brain aging and in Alzheimer’s disease in order to develop disease-modifying treatments that target normalization of biometal distribution and metal-protein interactions in the brain.


Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.
Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, Simkin I, Stein TD, Alvarez VE, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC, Clinical presentation of chronic traumatic encephalopathy, Neurology, 81(13), September 24, 2013, 1122-1129