John Chen, M.D. Ph.D.

Associate Professor, Harvard Medical School  

Attending Clinician (Neuroradiology), Mass General Hospital

Director, Institute for Innovation in Imaging, Mass General Hospital

Dr. Chen is an Associate Professor at Harvard Medical School and Attending Clinician (Neuroradiology) at MGH. Dr. Chen is a graduate of the University of Illinois (MD, PhD in physical chemistry) and completed his radiology residency at MGH in 2004 and neuroradiology fellowship also at MGH in 2005. He has won multiple awards including the MGH Wyman Award, RSNA and Dana Foundation Awards, as well as grants from the NIH and DoD. He is the director of the newly established Institute for Innovation in Imaging at MGH. Dr. Chen's laboratory performs basic and translational studies to better understand neuroinflammation. In particular, the laboratory investigates the roles of molecular pathways and innate immune processes related to activated microglia in important neurological diseases such as Alzheimer's disease and multiple sclerosis. A key aspect of the research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately Dr. Chen hopes to advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.

Funded Research

Project Description Researchers Funding
Myeloperoxidase, imaging and treatment target for Alzheimer’s Disease
Alzheimer’s disease (AD) is a challenging disease to diagnose and treat. Recent studies have shown that
innate immunity and inflammation play key roles in the pathogenesis of AD. Myeloperoxidase (MPO) is
a highly damaging substance secreted abundantly in inflammatory conditions by activated microglia and
astrocytes. MPO has been associated with beta-amyloid in both AD and animal models. MPO is more
abundant in female AD patients and those showing cognitive decline, and is also strongly implicated in
2014
$100,000