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Hansang Cho, Ph.D.

Dr. Cho is an Assistant Professor in the Mechanical Engineering and Engineering Science, Biological Sciences, The Nanoscale Science Program at the University of North Carolina at Charlotte. He is also a Visiting Research Scientist at Harvard Medical School and the National University of Singapore. Hansang Cho’s research focuses on organ-on-chips for the study of neurosciences and cancer biology, and innovative mechanisms and nanobiosensors involving multiple physics for healthcare diagnostics and environmental sustainability. He recently developed brain-on-chips: a microglia-on-a-chip, a 3D blood-brain barrier on-a-chip, and a neuron-on-a-chip. He is further challenging complicated multicellular interactions in neurodegenerative diseases by combining the developed brain-on-chips. He received his B.S. and M.S in Mechanical Engineering from Seoul Nat’l University, Ph.D. in Bioengineering from University of California at Berkeley, and a postdoctoral training at Harvard Medical School. He received Cure Alzheimer’s Fund award, CRI Duke Energy Special Initiatives Funding awards, Lawrence scholar program fellowship from Lawrence Livermore National Laboratory, Fellowship supported by Intel Inc., and Study Abroad Scholarship by the Korean National Institute for International Education.

Related Research:

Study of Reactive Astrocytes-Derived Oxidative Stress and Proinflammation Leading to Neurodegenerative Microglial Activation in Alzheimer’s Disease Hansang Cho 2018-12-24 A Microfluidics-Based Human Brain Cell 3-D Culture System in Alzheimer’s Disease Hansang Cho 2018-08-27 A 3-D Human Neural Cell Culture System for Studying Neuron-Microglia Interaction in Alzheimer’s Disease Hansang Cho 2015-09-30

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Study of Reactive Astrocytes-Derived Oxidative Stress and Proinflammation Leading to Neurodegenerative Microglial Activation in Alzheimer’s Disease 2015 - 2019

$852,350
A Microfluidics-Based Human Brain Cell 3-D Culture System in Alzheimer’s Disease 2017

$152,350
A 3-D Human Neural Cell Culture System for Studying Neuron-Microglia Interaction in Alzheimer’s Disease 2015, 2016

$300,000

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Kang, Y. J., Hyeon, S. J., McQuade, A., Lim, J., Baek, S. H., Diep, Y. N., Do, K. V., Jeon, Y., Jo, D. G., Lee, C. J., Blurton-Jones, M., Ryu, H., & Cho, H. Neurotoxic Microglial Activation via IFNγ-Induced Nrf2 Reduction Exacerbating Alzheimer’s Disease, Advanced Science, March 14, 2024, Read More

Park, J., Wetzel, I., Marriott, I., Dréau, D., D'Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. A 3D Human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease, Nature Neuroscience, June 27, 2018, Read More

Park, J., Wetzel, I., Dréau, D., & Cho, H. 3D Miniaturization of Human Organs for Drug Discovery, Advanced Healthcare Materials, September 8, 2017, Read More

Park, J., Baik, S. H., Mook-Jung, I., Irimia, D., & Cho, H. Mimicry of Central-Peripheral Immunity in Alzheimer’s Disease and Discovery of Neurodegenerative Roles in neutrophil, Frontiers in Immunology, September 25, 2019, Read More

Chun, H., Marriott, I., Lee, C. J., & Cho, H. Elucidating the interactive roles of glia in Alzheimer’s disease using established and newly developed experimental models, Frontiers in Neurology, September 26, 2018, Read More

Kang, Y. J., Cutler, E. G., & Cho, H. Therapeutic nanoplatforms and delivery strategies for neurological disorders, Nano Convergence, November 30, 2018, Read More

McQuade, A., Kang, Y. J., Hasselmann, J., Jairaman, A., Sotelo, A., Coburn, M., Shabestari, S. K., Chadarevian, J. P., Fote, G., Tu, C. H., Danhash, E., Silva, J., Martinez, E., Cotman, C., Prieto, G. A., Thompson, L. M., Steffan, J. S., Smith, I., Davtyan, H., Cahalan, M., … Cho, H., Blurton-Jones, M. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease, Nature Communications, October 23, 2020, Read More

Chun, H., Im, H., Kang, Y. J., Kim, Y., Shin, J. H., Won, W., Lim, J., Ju, Y., Park, Y. M., Kim, S., Lee, S. E., Lee, J., Woo, J., Hwang, Y., Cho, H., Jo, S., Park, J. H., Kim, D., Kim, D. Y., Seo, J. S., Gwag, B. J., Kim, Y. S., Park K. D., Kaang, B. K., Cho, H., Ryu, H., & Lee, C. J. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H 2 O 2- production, Nature Neuroscience, November 16, 2020, Read More

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