Associate Professor of Neuroscience, Alzheimer’s Disease Research Laboratory, Department of Neuroscience, Tufts University School of Medicine
Dr. Tesco’s group has shown how brain cell death caused by strokes or head injuries can lead to the production of amyloid-beta through the dysregulation of BACE levels in the brain. She identified a novel mechanism of regulation of BACE levels and activity by the trafficking molecule GGA3 (golgi-localized gamma-ear-containing ARF binding protein 3). More recently, Dr. Tesco’s laboratory has demonstrated the role of ubiquitin in the regulation of BACE1 degradation via the GGA pathway. This pathway may be a way to regulate beta-secretase activity therapeutically.