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Eckhard Mandelkow, Ph.D.

Senior Group Leader, German Center for Neurodegenerative Diseases (DZNE), Germany

Dr. Eckhard Mandelkow studied physics in Braunschweig, New Orleans, and Hamburg, and received his doctoral degree at the Max Planck Institute for Medical Research in Heidelberg (for work on the structure of tobacco mosaic virus). This was followed by postdoctoral training at Brandeis University in Waltham, MA (on the structure of cytoskeletal proteins). Later he moved to the Deutsches Elektronensynchrotron (DESY) in Hamburg, Germany, and worked as director at the Max Planck Unit for Structural Molecular Biology, professor at Hamburg University, and scientific member of the Max Planck Society. His research focuses on structural molecular biology by X-rays using synchrotron radiation, image reconstruction and electron microscopy; cytoskeleton (microtubules, motor proteins); the structure, function, and aggregation of tau protein and protein kinases in Alzheimer disease; and the development of tau aggregation inhibitors. He is recipient of a 2010 Metlife Award and a 2011 Potamkin Award. In 2011, he joined the German Center for Neurodegenerative Diseases in Bonn (DZNE) as a Principal Investigator. For publications, see www.mpasmb-hamburg.mpg.de.

Related Research:

Reversal of Tau Pathology by an Adenosine A1 Receptor Antagonist Eva-Maria Mandelkow Anja Schneider Eckhard Mandelkow 2018-12-18 Tau Missorting in AD—Causes and Consequences Eckhard Mandelkow Eva-Maria Mandelkow 2016-01-11

Funded Research

These projects were made possible from Cure Alzheimer's Fund support.

Project Description Researchers Funding
Reversal of Tau Pathology by an Adenosine A1 Receptor Antagonist 2018, 2020

$575,000
Tau Missorting in AD—Causes and Consequences 2015, 2017

$322,500

Selected Publications

These published papers resulted from Cure Alzheimer’s Fund support.

Wischhof, L., Adhikari, A., Mondal, M., Marsal-Cots, A., Biernat, J., Mandelkow, E. M., Mandelkow, E., Ehninger, D., Nicotera, P., & Bano, D. Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau, Journal of Biological Chemistry, February 24, 2022, Read More

Wang, Y., Balaji, V., Kaniyappan, S., Krüger, L., Irsen, S., Tepper, K., Chandupatla, R., Maetzler, W., Schneider, A., Mandelkow, E., & Mandelkow, E. M. The release and trans-synaptic transmission of Tau via exosomes, Molecular Neurodegeneration, January 13, 2017, Read More

Kaniyappan, S., Tepper, K., Biernat, J., Chandupatla, R. R., Hübschmann, S., Irsen, S., Bicher, S., Klatt, C., Mandelkow, E. M., & Mandelkow, E. FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments, Molecular Neurodegeneration, July 16, 2020, Read More

Aillaud, I., Kaniyappan, S., Chandupatla, R. R., Ramirez, L. M., Alkhashrom, S., Eichler, J., Horn, A. H. C., Zweckstetter, M., Mandelkow, E., Sticht, H., & Funke, S. A. A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro, Alzheimer’s Research & Therapy, January 21, 2022, Read More

Wegmann, S., Biernat, J., & Mandelkow, E. A current view on Tau protein phosphorylation in Alzheimer’s disease., Current Opinion in Neurobiology, April 20, 2021, Read More

Sallaberry, C. A., Voss, B. J., Majewski, J., Biernat, J., Mandelkow, E., Chi, E. Y., & Vander Zanden, C. M. Tau and Membranes: Interactions That Promote Folding and Condensation, Frontiers in Cell and Developmental Biology, September 21, 2021, Read More

Kaniyappan, S., Balaji, V., Wang, Y., & Mandelkow, E. Microfluidic Chamber Technology to Study Missorting and Spreading of Tau Protein in Alzheimer’s Disease, Methods in Molecular Biology, October 31, 2022, Read More

Anglada-Huguet, M., Rodrigues, S., Hochgräfe, K., Mandelkow, E., & Mandelkow, E. M. Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice, Alzheimer's & Dementia, April 19, 2021, Read More

Balaji, V., Kaniyappan, S., Mandelkow, E., Wang, Y., & Mandelkow, E. M. Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems, Autophagy, September 1, 2018, Read More

Endepols, H., Anglada-Huguet, M., Mandelkow, E., Neumaier, B., Mandelkow, E. M., & Drzezga, A. Fragmentation of functional resting state brain networks in a transgenic mouse model of tau pathology: A metabolic connectivity study using [18F]FDG-PET, Experimental Neurology, December 3, 2023, Read More

Anglada-Huguet, M., Endepols, H., Sydow, A., Hilgers, R., Neumaier, B., Drzezga, A., Kaniyappan, S., Mandelkow, E., & Mandelkow, E. M. Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy, International Journal of Molecular Sciences, May 25, 2023, Read More

Endepols, H., Anglada-Huguet, M., Mandelkow, E., Schmidt, Y., Krapf, P., Zlatopolskiy, B. D., Neumaier, B., Mandelkow, E. M., & Drzezga, A. Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study, Molecular Neurodegeneration, March 21, 2022, Read More

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