Professor of Pharmacology
University of California, San Diego
Dr. Newton studies the molecular mechanisms underlying how cells process information in health and in disease. Cellular homeostasis depends on precise control of the balance between “go” and “stop” signals controlled by protein kinases and protein phosphatases, enzymes with opposing functions. Deregulation of this balance leads to pathophysiological states, driving either pro-survival diseases such as cancer or degenerative diseases such as Alzheimer’s disease. The Newton lab focuses, in particular, on the structure, function, and regulation of protein kinase C and how aberrant function contributes to the pathophysiologies of cancer and Alzheimer’s disease. Understanding the molecular basis for how protein kinase C is deregulated in these diseases has potential for novel therapeutic strategies. Dr. Alexandra Newton received her Ph.D. in Chemistry from Stanford University and her postdoctoral training in Daniel E. Koshland's laboratory at the University of California, Berkeley.